Figure 3From: Sildenafil ameliorates biomarkers of genotoxicity in an experimental model of spontaneous atherosclerosisDetection of DNA damage in liver cells assessed by alkaline comet assay. (A) Typical comets showing higher DNA fragmentation in apoE-/- vehicle compared to control WT, which contrasts with apoE-/- sildenafil; (B) Bar graph showing the mean of percentage of DNA in tail; (C) Bar graph showing the mean of tail moment (in a.u.); (D) Bar graph showing the mean of the number of comets with moderate-to-high damage (more than 25% of DNA in the tail). The values are presented as means ± SEM; 6 to 8 animals per group. *p < 0.05 and **p < 0.01, ANOVA).Back to article page