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Table 1 Newcastle - Ottawa quality assessment scale case–control studies

From: Apolipoprotein M T-778C polymorphism is associated with serum lipid levels and the risk of coronary artery disease in the Chinese population: a meta-analysis

Criteria

Score

Selection

 

1) Is the case definition adequate?

 

  a) yes, with independent validation

  b) yes, eg record linkage or based on self reports

 

  c) no description

 

2) Representativeness of the cases

 

  a) consecutive or obviously representative series of cases

  b) potential for selection biases or not stated

 

3) Selection of controls

 

  a) community controls

  b) hospital controls

 

  c) no description

 

4) Definition of controls

 

  a) no history of disease (endpoint)

  b) no description of source

 

Comparability

 

1) Comparability of cases and controls on the basis of the design or analysis

 

  a) study controls for the most important factor

  b) study controls for any additional factor

Exposure

 

1) Ascertainment of exposure

 

  a) secure record (eg surgical records)

  b) structured interview where blind to case/control status

  c) interview not blinded to case/control status

 

  d) written self report or medical record only

 

  e) no description

 

2) Same method of ascertainment for cases and controls

 

  a) yes

  b) no

 

3) Non-response rate

 

  a) same rate for both groups

  b) non respondents described

 

  c) rate different and no designation