Table 2 Effect of VMTP preparation on body weight, heart weight and coronary flow (CF)
Parameter | Normolipidemia | Hyperlipidemia | Significance | ||
|---|---|---|---|---|---|
Placebo | VMTP | Placebo | VMTP | ||
Body weight (g) | 472 ± 56 | 461 ± 25 | 480 ± 58 | 480 ± 35 | ns |
Heart weight (g) | 1.59 ± 0.75 | 1.49 ± 0.55 | 1.6 ± 0.76 | 1.66 ± 0.90 | ns |
(Heart weight/body weight)*1000 | 3.38 ± 0.12 | 3.23 ± 0.17 | 3.33 ± 0.10 | 3.38 ± 0.15 | ns |
CF (mL/min) – before ischemia | 17.4 ± 1.3 | 18.9 ± 1.5 | 19.3 ± 2.6 | 19.1 ± 2.2 | ns |
CF (mL/min) – first minute of ischemia | 15.7 ± 2.1 | 20.3 ± 2.3 | 17.4 ± 4.2 | 19.9 ± 3.4 | ns |
CF (mL/min) – during ischemia | 19.7 ± 1.2 | 20.6 ± 1.8 | 20.5 ± 2.3 | 25.2 ± 4.0 | ns |
CF (mL/min) - end of reperfusion | 22.0 ± 5.8 | 16.8 ± 2.0 | 14.7 ± 2.2 | 20.3 ± 2.4 | ns |