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Table 1 Antioxidant and oxidative stress biomarkers in blood and liver of Wistar rats fed the oil supplements

From: Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

Biomarkers

EPA/DHA 1:1

EPA/DHA 2:1

EPA/DHA 1:2

Soybean oil

Linseed oil

 

Mean ± SD

Mean ± SD

p

Mean ± SD

P

Mean ± SD

p

Mean ± SD

p

Erythrocytes

SOD (U/g Hb)

2129.2 ± 586.5

1880.9 ± 341.2

 

1226.1 ± 517.4

a0.023

1443.8 ± 426.2

 

1230.6 ± 283.9

a0.017

CAT (mmol/min/g Hb)

57.4 ± 11.1

76.7 ± 28.2

 

61.4 ± 13.2

 

41.5 ± 34.6

 

37.2 ± 20.9

 

GR (U/g Hb)

0.40 ± 0.08

0.734 ± 0.21

 

0.63 ± 0.35

 

0.93 ± 0.18

 

0.75 ± 0.20

 

GPx (U/g Hb)

107.1 ± 15.0

116.7 ± 30.7

a0.007

67.7 ± 34.5

a0.026

101.5 ± 38.2

 

71.1 ± 9.6

a0.002

    

b0.007

   

b0.001

Plasma

ORAC (μmol TE/ml plasma)

48.15 ± 16.96

23.56 ± 5.97

a0.023

26.39 ± 9.01

a0.016

30.32 ± 9.64

a0.049

24.71 ± 9.70

a0.033

LDL-ox (ng/mL)

161.53 ± 30.9

212.25 ± 57.4

 

239.43 ± 70.02

 

109.03 ± 27.34

b0.007

94.52 ± 14.08

b0.001

      

c0.001

 

c0.001

Liver

MDA (μg MDA/ g tissue)

10.29 ± 2.82

7.57 ± 2.55

 

8.81 ± 3.28

 

8.12 ± 2.53

 

6.53 ± 1.24

 
  1. The data are expressed as mean ± SD (standard deviation). a: difference with respect to EPA/DHA 1:1 supplementation; b: differences with respect to EPA/DHA 2:1 supplementation; c: differences with respect to EPA/DHA 1:2 supplementation.