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Table 2 Cardiovascular disease (CVD) risk factors in circulation in Wistar rats fed the different oil supplements

From: Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

  EPA/DHA 1:1 EPA/DHA 2:1 EPA/DHA 1:2 Soybean oil Linseed oil
Biomarkers Mean ± SD Mean ± SD Mean ± SD p Mean ± SD P Mean ± SD p
CV RISK FACTORS
Lipid profile
TG (mg/dL) 86.3 ± 65.1 124.5 ± 102.2 83.1 ± 10.4   108.5 ± 51.9   73.5 ± 25.2  
CHOL (mg/dL) 93.3 ± 26.5 98.0 ± 14.8 112.3 ± 20.8   125.8 ± 16.5   118.5 ± 13.5  
LDLc (mg/dL) 7.64 ± 3.3 7.4 ± 0.8 8.30 ± 1.3   10.39 ± 2.2   7.4 ± 1.6  
HDLc (mg/dL) 37.4 ± 11.1 50.4 ± 25.9 47.3 ± 8.1   51.3 ± 7.8   46.8 ± 5.5  
LDLc/HDLc 0.19 ± 0.5 0.20 ± 0.01 0.17 ± 0.01   0.20 ± 0.2   0.19 ± 0.1  
ApoA1 (mg/mL) 43.0 ± 11.4 51.7 ± 11.9 47.9 ± 13.8   51.4 ± 13.3   30.6 ± 2.1  
ApoB100 (mg/mL) 116.5 ± 16.8 137.0 ± 6.4 139.4 ± 23.8   126.8 ± 13.9   152.7 ± 35.7  
ApoB100/ApoA1 2.79 ± 0.51 2.75 ± 0.54 3.10 ± 1.01   2.67 ± 1.11   5.02 ± 1.29 a0.029
        b0.019
        d0.029
Glycaemia
Glucose increase (mmol/L) -0.75 ± 0.42 -0.15 ± 0.34 0.27 ± 0.49 a0.001 0.53 ± 0.25 a < 0.001 - 0.20 ± 0.31 d0.032
Glycated Haemoglobin (%) 4.14 ± 0.24 4.43 ± 0.72 4.17 ± 0.30   6.39 ± 0.99 a0.003 6.34 ± 1.84 a0.025
      b0.007   b0.05
      c0.004   c0.032
Insulin increase (ng/mL) 1.40 ± 0.8 0.15 ± 1.90 0.42 ± 0.4   0.9 ± 1.5   0.41 ± 0.5  
Homa index 7.0 ± 3.0 4.1 ± 1.8 3.8 ± 1.5   6.9 ± 3.8   2.9 ± 1.1 a0.004
        d0.032
  1. The data are expressed as mean ± SD (standard deviation). a: differences with respect to EPA/DHA 1:1 supplementation; b: differences with respect to EPA/DHA 2:1 supplementation; c: differences with respect to EPA/DHA 1:2 supplementation; d: differences with respect to soybean oil supplementation.