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Table 2 Cardiovascular disease (CVD) risk factors in circulation in Wistar rats fed the different oil supplements

From: Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

 

EPA/DHA 1:1

EPA/DHA 2:1

EPA/DHA 1:2

Soybean oil

Linseed oil

Biomarkers

Mean ± SD

Mean ± SD

Mean ± SD

p

Mean ± SD

P

Mean ± SD

p

CV RISK FACTORS

Lipid profile

TG (mg/dL)

86.3 ± 65.1

124.5 ± 102.2

83.1 ± 10.4

 

108.5 ± 51.9

 

73.5 ± 25.2

 

CHOL (mg/dL)

93.3 ± 26.5

98.0 ± 14.8

112.3 ± 20.8

 

125.8 ± 16.5

 

118.5 ± 13.5

 

LDLc (mg/dL)

7.64 ± 3.3

7.4 ± 0.8

8.30 ± 1.3

 

10.39 ± 2.2

 

7.4 ± 1.6

 

HDLc (mg/dL)

37.4 ± 11.1

50.4 ± 25.9

47.3 ± 8.1

 

51.3 ± 7.8

 

46.8 ± 5.5

 

LDLc/HDLc

0.19 ± 0.5

0.20 ± 0.01

0.17 ± 0.01

 

0.20 ± 0.2

 

0.19 ± 0.1

 

ApoA1 (mg/mL)

43.0 ± 11.4

51.7 ± 11.9

47.9 ± 13.8

 

51.4 ± 13.3

 

30.6 ± 2.1

 

ApoB100 (mg/mL)

116.5 ± 16.8

137.0 ± 6.4

139.4 ± 23.8

 

126.8 ± 13.9

 

152.7 ± 35.7

 

ApoB100/ApoA1

2.79 ± 0.51

2.75 ± 0.54

3.10 ± 1.01

 

2.67 ± 1.11

 

5.02 ± 1.29

a0.029

       

b0.019

       

d0.029

Glycaemia

Glucose increase (mmol/L)

-0.75 ± 0.42

-0.15 ± 0.34

0.27 ± 0.49

a0.001

0.53 ± 0.25

a < 0.001

- 0.20 ± 0.31

d0.032

Glycated Haemoglobin (%)

4.14 ± 0.24

4.43 ± 0.72

4.17 ± 0.30

 

6.39 ± 0.99

a0.003

6.34 ± 1.84

a0.025

     

b0.007

 

b0.05

     

c0.004

 

c0.032

Insulin increase (ng/mL)

1.40 ± 0.8

0.15 ± 1.90

0.42 ± 0.4

 

0.9 ± 1.5

 

0.41 ± 0.5

 

Homa index

7.0 ± 3.0

4.1 ± 1.8

3.8 ± 1.5

 

6.9 ± 3.8

 

2.9 ± 1.1

a0.004

       

d0.032

  1. The data are expressed as mean ± SD (standard deviation). a: differences with respect to EPA/DHA 1:1 supplementation; b: differences with respect to EPA/DHA 2:1 supplementation; c: differences with respect to EPA/DHA 1:2 supplementation; d: differences with respect to soybean oil supplementation.