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Table 3 Cardiovascular disease (CVD) risk biomarkers in circulation in Wistar rats fed the different oil supplements

From: Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

  EPA/DHA 1:1 EPA/DHA 2:1 EPA/DHA 1:2 Soybean oil Linseed oil
Biomarkers Mean ± SD Mean ± SD Mean ± SD p Mean ± SD P Mean ± SD p
CVD RISK MARKERS
Inflammation
CRP (μg/mL) 147.0 ± 20.5 147.1 ± 22.4 140.1 ± 52.7   172.9 ± 38.2   142.9 ± 52.0  
Thrombotic activity
PAI-1 (μg/mL) 7.48 ± 1.3 8.75 ± 1.8 9.18 ± 1.3   6.45 ± 0.8 c0.030 7.76 ± 1.1  
Endothelial dysfunction
sVCAM (μg/mL) 3.41 ± 0.7 3.01 ± 0.4 4.40 ± 1.3 b0.046 3.36 ± 1.7   2.10 ± 0.4 a0.001
        b0.001
        c0.003
sICAM (ng/mL) 0.59 ± 0.2 0.61 ± 0.2 0.53 ± 0.2   0.52 ± 0.1   0.59 ± 0.3  
  1. The data are expressed as mean ± SD (standard deviation). a: differences with respect to EPA/DHA 1:1 supplementation; b: differences with respect to EPA/DHA 2:1 supplementation; c: differences with respect to EPA/DHA 1:2 supplementation.