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Table 3 Cardiovascular disease (CVD) risk biomarkers in circulation in Wistar rats fed the different oil supplements

From: Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats

 

EPA/DHA 1:1

EPA/DHA 2:1

EPA/DHA 1:2

Soybean oil

Linseed oil

Biomarkers

Mean ± SD

Mean ± SD

Mean ± SD

p

Mean ± SD

P

Mean ± SD

p

CVD RISK MARKERS

Inflammation

CRP (μg/mL)

147.0 ± 20.5

147.1 ± 22.4

140.1 ± 52.7

 

172.9 ± 38.2

 

142.9 ± 52.0

 

Thrombotic activity

PAI-1 (μg/mL)

7.48 ± 1.3

8.75 ± 1.8

9.18 ± 1.3

 

6.45 ± 0.8

c0.030

7.76 ± 1.1

 

Endothelial dysfunction

sVCAM (μg/mL)

3.41 ± 0.7

3.01 ± 0.4

4.40 ± 1.3

b0.046

3.36 ± 1.7

 

2.10 ± 0.4

a0.001

       

b0.001

       

c0.003

sICAM (ng/mL)

0.59 ± 0.2

0.61 ± 0.2

0.53 ± 0.2

 

0.52 ± 0.1

 

0.59 ± 0.3

 
  1. The data are expressed as mean ± SD (standard deviation). a: differences with respect to EPA/DHA 1:1 supplementation; b: differences with respect to EPA/DHA 2:1 supplementation; c: differences with respect to EPA/DHA 1:2 supplementation.
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Lipids in Health and Disease

ISSN: 1476-511X