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Figure 4 | Lipids in Health and Disease

Figure 4

From: Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics

Figure 4

Dietary supplementation with borage and echium seed oils decreases FcϵRI-dependent cysteinyl leukotriene generation by peripheral blood basophils. Cysteinyl leukotriene generation is shown prior to (, closed circles) and one week (∆, open triangles), two weeks (□, open squares), and three weeks (, open circles) after dietary supplementation with one of four borage and echium seed oil combinations (Groups 1–4, respectively) in response to buffer alone, control IgG1 (1.0 μg/ml, IgG), and 15A5, an activating antibody against FcϵRI (0.01 to 1.0 μg/ml). Due to technical errors, data are not available for one subject in each of groups 1, 3, and 4. In addition, basophils from one subject in each of groups 3 and 4 failed to release leukotrienes upon stimulation, a well described phenomenon due to impaired signaling through Syk. Data are expressed as a percentage of maximal cysteinyl leukotriene generation in each subject and are expressed as means ± SEM. Statistically significant suppression of ex vivo leukotriene generation was noted (p < 0.0001) with a significant difference between groups (p < 0.0001).

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