Dietary supplementation with borage and echium oils decreases A23187-stimulated total leukotriene generation by peripheral blood neutrophil. Leukotriene generation is shown prior to (●, closed circles) and one week (∆, open triangles), two weeks (□, open squares), and three weeks (○, open circles) after dietary supplementation with one of four borage and echium seed oil combinations (Groups 1–4, respectively) in response to buffer alone and increasing concentrations of the calcium ionophore, A23187 (0.1 to 10 μM). Total leukotriene generation is the sum of LTB4, 5-HETE, and, where measurable, all-trans-LTB4 isomers. Data are expressed as means ± SEM. Statistically significant suppression of ex vivo leukotriene generation was noted (p < 0.0001) with a significant difference in effect between groups (p = 0.02).