Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats

Table 1 Fatty acid profiles of SLOil, FOil, regular chow, and tumor tissue

Fatty acids (g/100g of total fatty acids)	SLOil	FOil	Regular chow	Tumor tissue
Fatty acids (g/100g of total fatty acids)	SLOil	FOil	Regular chow	W	WSLO	WFO	WSLO + FO
Lauric (12:0)	1.3 ± 0.0	3.2 ± 0.3	1.1 ± 0.0	0.4 ± 0.1	0.5 ± 0.1	0.4 ± 0.1	0.4 ± 0.1
Miristic (14:0)	5.9 ± 0.1	8.7 ± 2.6	-	1.1 ± 0.4	0.7 ± 0.0	1.0 ± 0.2	1.0 ± 0.2
Palmitic (16:0)	34.2 ± 3.7	24.8 ± 2.9	22.3 ± 0.3	24.1 ± 0.9	26.1 ± 2.5	22.8 ± 1.5	26.5 ± 1.5
Palmitoleic (16:1n-7)	4.7 ± 0.4	5.5 ± 0.4	-	2.7 ± 0.1	1.4 ± 0.5	1.7 ± 0.1	1.6 ± 0.2
Stearic (18:0)	2.2 ± 0.1	2.8 ± 0.1	1.9 ± 0.0	15.7 ± 1.9	15.1 ± 0.9	8.0 ± 0.9	9.1 ± 1.4
Oleic (18:1n-9)	29.6 ± 3.1	11.8 ± 0.7	20.4 ± 0.9	24.8 ± 2.6	24.1 ± 3.0	24.8 ± 0.9	25.7 ± 0.9
Linoleic (18:2n-6)	2.1 ± 0.2	2.0 ± 0.5	50.6 ± 3.2	18.5 ± 1.3	22.9 ± 3.1	21.8 ± 2.3	22.6 ± 2.5
α-Linolenic (18:3n-3)	0.3 ± 0.0	0.8 ± 0.0	3.9 ± 0.2	0.5 ± 0.0	0.2 ± 0.0	1.0 ± 0.07	0.9 ± 0.2
Arachidonic (20:4n-6)	1.1 ± 0.1	0.9 ± 0.0	0.1 ± 0.0	16.9 ± 1.3	8.4 ± 2.1^a	3.5 ± 0.8^a	3.9 ± 1.4^a
EPA (20:5n-3)	5.2 ± 0.5	21.3 ± 1.1	-	0.3 ± 0.1	0.6 ± 0.1	1.2 ± 0.2^a	0.8 ± 0.2^a
DHA (22:6n-3)	11.4 ± 1.0	17.9 ± 1.4	-	1.0 ± 0.0	2.0 ± 0.2	4.2 ± 0.7^ab	4.2 ± 0.5^ab

Tumor tissue from Walker 256 tumor-bearing rats fed regular chow (W), supplemented with SLOil (WSLO), FOil (WFO) and both (WSLO + FO), determined by HPLC (high performance liquid chromatography). Data are presented as mean ± SEM of 3 independent measurements (HPLC) of 3 rats per group (n = 9). ^ap < 0.05 compared to W; ^bp < 0.05 compared to WSLO.

ISSN: 1476-511X