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Table 3 Erythrocyte membrane fatty acid composition in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 weeks

From: Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats

Fatty acid ( % of total)

Lean

Obese

Main effects

 
 

CON

FLAX

FISH

SDA

CON

FLAX

FISH

SDA

Genotype

Diet

Interaction

LA [18:2(n-6)]

9.50 ± 0.28

9.61 ± 0.28

9.72 ± 0.28

8.26 ± 0.29

7.76 ± 0.30

7.97 ± 0.29

8.21 ± 0.29

6.73 ± 0.31

P < 0.0001†

P < 0.0001i

P = 0.96

ALA [18:3(n-3)]

0.04 ± 0.07a

0.43 ± 0.07b

0.10 ± 0.07a

0.64 ± 0.07c

0.14 ± 0.07a

0.70 ± 0.07c

0.21 ± 0.07a

0.61 ± 0.08bc

P = 0.24

P < 0.0001ii

ΔP = 0.079

GLA [18:3(n-3)]

0.04 ± 0.02

0.04 ± 0.02

0.04 ± 0.02

0.30 ± 0.02

0.05 ± 0.02

0.04 ± 0.02

0.04 ± 0.02

0.20 ± 0.02

P = 0.78

P < 0.0001iii

P = 0.52

SDA [18:4(n-3)]

0.03 ± 0.05

0.03 ± 0.05

0.03 ± 0.05

0.40 ± 0.05

0.03 ± 0.03

0.02 ± 0.05

0.03 ± 0.05

0.40 ± 0.05

P = 0.74

P < 0.0001iii

P = 0.76

AA [20:4(n-6)]

25.63 ± 0.51

22.21 ± 0.51

15.90 ± 0.50

20.67 ± 0.52

24.91 ± 0.54

21.1 ± 0.51

14.80 ± 0.52

18.13 ± 0.56

P = 0.056

P < 0.0001iv

P = 0.13

EPA [20:5(n-3)]

0.05 ± 0.11a

1.06 ± 0.11b

5.14 ± 0.11f

2.80 ± 0.11d

0.23 ± 0.12a

1.45 ± 0.11c

5.41 ± 0.12f

3.98 ± 0.12e

P = 0.0017‡

P < 0.0001v

ΔP < 0.0001

DPA [22:5(n-3)]

1.02 ± 0.16a

3.67 ± 0.16cd

3.74 ± 0.16d

5.44 ± 0.17e

1.19 ± 0.17a

3.08 ± 0.17b

3.17 ± 0.18bc

4.64 ± 0.18e

P = 0.052

P < 0.0001vi

ΔP = 0.0050

DHA [22:6(n-3)]

2.51 ± 0.14

3.74 ± 0.14

5.80 ± 0.14

2.31 ± 0.14

2.91 ± 0.15

4.33 ± 0.14

6.50 ± 0.14

3.28 ± 0.15

P = 0.0010‡

P < 0.0001vii

P = 0.10

∑SFA

47.53 ± 0.39

47.58 ± 0.39

47.17 ± 0.38

47.49 ± 0.40

47.35 ± 0.41

47.23 ± 0.39

47.67 ± 0.40

47.31 ± 0.43

P = 0.93

P = 0.99

P = 0.56

∑MUFA

9.62 ± 0.39

9.94 ± 0.39

11.00 ± 0.39

10.14 ± 0.40

11.91 ± 0.42

12.12 ± 0.40

12.12 ± 0.40

12.36 ± 0.43

P = 0.0006‡

P = 0.11

P = 0.23

∑n3PUFA

3.63 ± 0.19

8.92 ± 0.19

14.81 ± 0.19

11.63 ± 0.20

4.48 ± 0.20

9.59 ± 0.19

15.31 ± 0.20

12.88 ± 0.21

P = 0.0029‡

P < 0.0001v

P = 0.10

∑n6PUFA

41.23 ± 0.45

37.23 ± 0.45

32.76 ± 0.44

33.01 ± 0.46

38.61 ± 0.48

35.33 ± 0.45

31.33 ± 0.46

30.67 ± 0.49

P = 0.0013†

P < 0.0001iv

P = 0.41

  1. ΔDifferent letters represent significance among means as determined by Bonferroni correction (P < 0.05).
  2. Genotype Effect: †Lean > Obese; ‡Obese > Lean.
  3. Diet Effect: iCON, FLAX, FISH > SDA; iiSDA, FLAX > CON, FISH; iiiSDA > CON, FLAX, FISH; ivCON > FLAX > SDA > FISH; vFISH > SDA > FLAX > CON; viSDA > FLAX, FISH > CON; viiFISH > FLAX > SDA, CON.
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Lipids in Health and Disease

ISSN: 1476-511X