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Table 3 Erythrocyte membrane fatty acid composition in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 weeks

From: Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats

Fatty acid ( % of total) Lean Obese Main effects  
  CON FLAX FISH SDA CON FLAX FISH SDA Genotype Diet Interaction
LA [18:2(n-6)] 9.50 ± 0.28 9.61 ± 0.28 9.72 ± 0.28 8.26 ± 0.29 7.76 ± 0.30 7.97 ± 0.29 8.21 ± 0.29 6.73 ± 0.31 P < 0.0001 P < 0.0001i P = 0.96
ALA [18:3(n-3)] 0.04 ± 0.07a 0.43 ± 0.07b 0.10 ± 0.07a 0.64 ± 0.07c 0.14 ± 0.07a 0.70 ± 0.07c 0.21 ± 0.07a 0.61 ± 0.08bc P = 0.24 P < 0.0001ii ΔP = 0.079
GLA [18:3(n-3)] 0.04 ± 0.02 0.04 ± 0.02 0.04 ± 0.02 0.30 ± 0.02 0.05 ± 0.02 0.04 ± 0.02 0.04 ± 0.02 0.20 ± 0.02 P = 0.78 P < 0.0001iii P = 0.52
SDA [18:4(n-3)] 0.03 ± 0.05 0.03 ± 0.05 0.03 ± 0.05 0.40 ± 0.05 0.03 ± 0.03 0.02 ± 0.05 0.03 ± 0.05 0.40 ± 0.05 P = 0.74 P < 0.0001iii P = 0.76
AA [20:4(n-6)] 25.63 ± 0.51 22.21 ± 0.51 15.90 ± 0.50 20.67 ± 0.52 24.91 ± 0.54 21.1 ± 0.51 14.80 ± 0.52 18.13 ± 0.56 P = 0.056 P < 0.0001iv P = 0.13
EPA [20:5(n-3)] 0.05 ± 0.11a 1.06 ± 0.11b 5.14 ± 0.11f 2.80 ± 0.11d 0.23 ± 0.12a 1.45 ± 0.11c 5.41 ± 0.12f 3.98 ± 0.12e P = 0.0017 P < 0.0001v ΔP < 0.0001
DPA [22:5(n-3)] 1.02 ± 0.16a 3.67 ± 0.16cd 3.74 ± 0.16d 5.44 ± 0.17e 1.19 ± 0.17a 3.08 ± 0.17b 3.17 ± 0.18bc 4.64 ± 0.18e P = 0.052 P < 0.0001vi ΔP = 0.0050
DHA [22:6(n-3)] 2.51 ± 0.14 3.74 ± 0.14 5.80 ± 0.14 2.31 ± 0.14 2.91 ± 0.15 4.33 ± 0.14 6.50 ± 0.14 3.28 ± 0.15 P = 0.0010 P < 0.0001vii P = 0.10
∑SFA 47.53 ± 0.39 47.58 ± 0.39 47.17 ± 0.38 47.49 ± 0.40 47.35 ± 0.41 47.23 ± 0.39 47.67 ± 0.40 47.31 ± 0.43 P = 0.93 P = 0.99 P = 0.56
∑MUFA 9.62 ± 0.39 9.94 ± 0.39 11.00 ± 0.39 10.14 ± 0.40 11.91 ± 0.42 12.12 ± 0.40 12.12 ± 0.40 12.36 ± 0.43 P = 0.0006 P = 0.11 P = 0.23
∑n3PUFA 3.63 ± 0.19 8.92 ± 0.19 14.81 ± 0.19 11.63 ± 0.20 4.48 ± 0.20 9.59 ± 0.19 15.31 ± 0.20 12.88 ± 0.21 P = 0.0029 P < 0.0001v P = 0.10
∑n6PUFA 41.23 ± 0.45 37.23 ± 0.45 32.76 ± 0.44 33.01 ± 0.46 38.61 ± 0.48 35.33 ± 0.45 31.33 ± 0.46 30.67 ± 0.49 P = 0.0013 P < 0.0001iv P = 0.41
  1. ΔDifferent letters represent significance among means as determined by Bonferroni correction (P < 0.05).
  2. Genotype Effect: Lean > Obese; Obese > Lean.
  3. Diet Effect: iCON, FLAX, FISH > SDA; iiSDA, FLAX > CON, FISH; iiiSDA > CON, FLAX, FISH; ivCON > FLAX > SDA > FISH; vFISH > SDA > FLAX > CON; viSDA > FLAX, FISH > CON; viiFISH > FLAX > SDA, CON.