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Table 9 Brain fatty acid profile in LZR and OZR rats fed CON, FLAX, FISH, or SDA diets for 12 week

From: Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats

Fatty acid ( % of total) Lean Obese Main effect  
  CON FLAX FISH SDA CON FLAX FISH SDA Genotype Diet Interaction
LA [18:2(n-6)] 0.005 ± 0.002 0.009 ± 0.002 0.005 ± 0.002 0.009 ± 0.002 0.007 ± 0.002 0.007 ± 0.001 0.010 ± 0.002 0.012 ± 0.002 P = 0.13 P = 0.48 P = 0.35
ALA [18:3(n-3)] 1.31 ± 0.030 1.36 ± 0.030 1.28 ± 0.028 1.23 ± 0.030 1.19 ± 0.030 1.20 ± 0.024 1.16 ± 0.030 1.05 ± 0.030 P < 0.0001 P < 0.0001i P = 0.58
SDA [18:4(n-3)] 0.16 ± 0.027 0.14 ± 0.027 0.18 ± 0.026 0.18 ± 0.027 0.08 ± 0.028 0.10 ± 0.022 0.13 ± 0.027 0.12 ± 0.027 P = 0.078 P = 0.30 P = 0.83
AA [20:4(n-6)] 11.02 ± 0.20de 10.69 ± 0.20cd 9.80 ± 0.19b 10.65 ± 0.20cd 11.19 ± 0.21e 10.27 ± 0.16bc 8.87 ± 0.20a 10.48 ± 0.20cd P = 0.16 P < 0.0001ii ΔP = 0.021
EPA [20:5(n-3)] 0.023 ± 0.01a 0.028 ± 0.01a 0.13 ± 0.01c 0.079 ± 0.01b 0.018 ± 0.01a 0.066 ± 0.0b 0.24 ± 0.01e 0.20 ± 0.01d P < 0.0001 P < 0.0001iii ΔP < 0.0001
DPA [22:5(n-3)] 0.13 ± 0.018a 0.28 ± 0.018b 0.46 ± 0.017c 0.66 ± 0.018e 0.13 ± 0.018a 0.33 ± 0.014b 0.56 ± 0.018d 0.81 ± 0.018f P = 0.0009 P < 0.0001iv ΔP < 0.0001
DHA [22:6(n-3)] 12.80 ± 0.22 13.53 ± 0.21 14.38 ± 0.21 13.53 ± 0.22 13.52 ± 0.22 13.61 ± 0.17 15.06 ± 0.22 13.90 ± 0.22 P = 0.077 P < 0.0001v P = 0.26
∑SFA 36.00 ± 0.27 35.78 ± 0.26 35.74 ± 0.25 35.73 ± 0.26 36.35 ± 0.27 36.06 ± 0.21 35.77 ± 0.26 36.83 ± 0.27 P = 0.16 P = 0.074vi P = 0.091
∑MUFA 19.90 ± 0.16 20.44 ± 0.15 20.84 ± 0.15 20.1 ± 0.15 19.61 ± 0.16 20.08 ± 0.12 20.03 ± 0.15 19.82 ± 0.16 P = 0.021 P < 0.0001vii P = 0.14
∑n3PUFA 14.62 ± 0.21 15.53 ± 0.20 16.61 ± 0.19 15.85 ± 0.20 15.08 ± 0.21 15.46 ± 0.16 17.23 ± 0.20 16.29 ± 0.21 P = 0.14 P < 0.0001iii P = 0.21
∑n6PUFA 11.02 ± 0.20bd 10.70 ± 0.20b 9.80 ± 0.19b 10.65 ± 0.20bc 11.20 ± 0.21d 10.28 ± 0.16c 8.88 ± 0.20a 10.49 ± 0.20b P = 0.17 P < 0.0001ii ΔP = 0.023
  1. ΔDifferent letters represent significance among means as determined by Bonferroni correction (P < 0.05).
  2. Genotype Effect: Lean > Obese; Obese > Lean.
  3. Diet Effect: iFLAX > CON > FISH > SDA; iiCON > FLAX, SDA > FISH; iiiFISH > SDA > FLAX > CON; ivSDA > FISH > FLAX > CON; vFISH > SDA, FLAX > CON; viSDA, CON > FISH, FLAX; viiFISH, FLAX > SDA, CON.