Skip to main content

Table 3 Association between the APOE rs439401 and rs4420638 SNPs and anthropometric, biochemical and clinical parameters in the ISOR study

From: Impact of APOE gene polymorphisms on the lipid profile in an Algerian population

 

rs439401

rs4420638

 

CC

CT

TT

p 1

p 2

AA

AG

GG

p 1

p 2

n

288

335

115

  

596

149

10

  

Weight (kg)

71.6 ± 14.5

71.5 ± 15.0

70.8 ± 13.6

0.87

0.68

71.7 ± 14.9

69.4 ± 13.4

67.7 ± 5.9

0.04

0.04

Waist (cm)

88.1 ± 12.6

87.7 ± 12.2

87.4 ± 12.4

0.83

0.66

88.0 ± 12.5

86.7 ± 11.9

83.5 ± 11.2

0.11

0.07

Hip (cm)

102.2 ± 10.0

102.0 ± 10.00

101.3 ± 9.1

0.56

0.45

102.2 ± 9.9

100.8 ± 9.3

97.0 ± 6.2

0.04

0.04

BMI (kg/m2)

26.0 ± 5.2

26.3 ± 5.1

26.0 ± 4.9

0.65

0.79

26.2 ± 5.2

25.4 ± 4.6

24.5 ± 2.9

0.05

0.08

Waist-to-hip ratio

0.86 ± 0.08

0.86 ± 0.10

0.86 ± 0.08

0.83

0.92

0.86 ± 0.08

0.86 ± 0.11

0.86 ± 0.11

0.99

0.64

Fasting glucose (mmol/L)*

5.04 ± 1.20

5.10 ± 1.52

5.06 ± 1.14

0.69

0.48

5.03 ± 1.26

5.20 ± 1.60

5.03 ± 0.70

0.18

0.34

Fasting insulin (μIU/mL)*

8.02 ± 6.09

8.57 ± 6.53

7.58 ± 5.62

0.72

0.7

8.07 ± 5.62

8.75 ± 8.28

6.61 ± 2.89

0.31

0.58

Triglycerides (mmol/L)

1.20 ± 0.51

1.14 ± 0.50

1.07 ± 0.47

0.005

0.25

1.14 ± 0.49

1.19 ± 0.55

1.21 ± 0.41

0.06

0.89

Total cholesterol (mmol/L)

4.50 ± 1.02

4.42 ± 0.86

4.35 ± 0.82

0.14

0.42

4.44 ± 0.90

4.43 ± 0.98

4.51 ±1.02

0.76

0.42

HDL-cholesterol (mmol/L)

1.24 ± 0.31

1.26 ± 0.33

1.27 ± 0.27

0.29

0.41

1.25 ± 0.30

1.27 ± 0.34

1.17 ± 0.24

0.82

0.55

LDL-cholesterol (mmol/L)

2.74 ± 0.97

2.66 ± 0.82

2.58 ± 0.82

0.11

0.31

2.69 ± 0.87

2.64 ± 0.88

2.78 ± 0.88

0.94

0.20

LDL-cholesterol/HDL-cholesterol ratio

2.39 ± 1.15

2.38 ± 2.12

2.17 ± 0.88

0.31

0.19

2.37 ± 1.76

2.25 ± 1.02

2.36 ± 0.52

0.65

0.09

SBP (mmHg)††

121.4 ± 16.4

120.9 ± 14.8

121.1 ± 15.1

0.66

0.44

120.9 ± 14.8

121.0 ± 17.6

128.1 ± 18.9

0.36

0.51

DBP (mmHg)††

75.4 ± 10.1

75.9 ± 8.7

76.4 ± 8.6

0.14

0.09

75.7 ± 9.0

75.7 ± 10.1

78.1 ± 12.2

0.56

0.58

  1. Data are expressed as the mean ± SD. SBP: systolic blood pressure, DBP: diastolic blood pressure.
  2. p1: p values were adjusted for age, gender, smoking status and physical activity for anthropometric variables. p values were adjusted for age, gender, BMI, smoking status and physical activity for biological and biochemical variables.
  3. p2: as above and additionally for APOE epsilon status.
  4. *subjects treated for diabetes were excluded (n=54).
  5. subjects treated with lipid-lowering drugs were excluded (n=36).
  6. ††subjects treated for hypertension were excluded (n=89).