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Table 3 Association between the APOE rs439401 and rs4420638 SNPs and anthropometric, biochemical and clinical parameters in the ISOR study

From: Impact of APOE gene polymorphisms on the lipid profile in an Algerian population

  rs439401 rs4420638
  CC CT TT p 1 p 2 AA AG GG p 1 p 2
n 288 335 115    596 149 10   
Weight (kg) 71.6 ± 14.5 71.5 ± 15.0 70.8 ± 13.6 0.87 0.68 71.7 ± 14.9 69.4 ± 13.4 67.7 ± 5.9 0.04 0.04
Waist (cm) 88.1 ± 12.6 87.7 ± 12.2 87.4 ± 12.4 0.83 0.66 88.0 ± 12.5 86.7 ± 11.9 83.5 ± 11.2 0.11 0.07
Hip (cm) 102.2 ± 10.0 102.0 ± 10.00 101.3 ± 9.1 0.56 0.45 102.2 ± 9.9 100.8 ± 9.3 97.0 ± 6.2 0.04 0.04
BMI (kg/m2) 26.0 ± 5.2 26.3 ± 5.1 26.0 ± 4.9 0.65 0.79 26.2 ± 5.2 25.4 ± 4.6 24.5 ± 2.9 0.05 0.08
Waist-to-hip ratio 0.86 ± 0.08 0.86 ± 0.10 0.86 ± 0.08 0.83 0.92 0.86 ± 0.08 0.86 ± 0.11 0.86 ± 0.11 0.99 0.64
Fasting glucose (mmol/L)* 5.04 ± 1.20 5.10 ± 1.52 5.06 ± 1.14 0.69 0.48 5.03 ± 1.26 5.20 ± 1.60 5.03 ± 0.70 0.18 0.34
Fasting insulin (μIU/mL)* 8.02 ± 6.09 8.57 ± 6.53 7.58 ± 5.62 0.72 0.7 8.07 ± 5.62 8.75 ± 8.28 6.61 ± 2.89 0.31 0.58
Triglycerides (mmol/L) 1.20 ± 0.51 1.14 ± 0.50 1.07 ± 0.47 0.005 0.25 1.14 ± 0.49 1.19 ± 0.55 1.21 ± 0.41 0.06 0.89
Total cholesterol (mmol/L) 4.50 ± 1.02 4.42 ± 0.86 4.35 ± 0.82 0.14 0.42 4.44 ± 0.90 4.43 ± 0.98 4.51 ±1.02 0.76 0.42
HDL-cholesterol (mmol/L) 1.24 ± 0.31 1.26 ± 0.33 1.27 ± 0.27 0.29 0.41 1.25 ± 0.30 1.27 ± 0.34 1.17 ± 0.24 0.82 0.55
LDL-cholesterol (mmol/L) 2.74 ± 0.97 2.66 ± 0.82 2.58 ± 0.82 0.11 0.31 2.69 ± 0.87 2.64 ± 0.88 2.78 ± 0.88 0.94 0.20
LDL-cholesterol/HDL-cholesterol ratio 2.39 ± 1.15 2.38 ± 2.12 2.17 ± 0.88 0.31 0.19 2.37 ± 1.76 2.25 ± 1.02 2.36 ± 0.52 0.65 0.09
SBP (mmHg)†† 121.4 ± 16.4 120.9 ± 14.8 121.1 ± 15.1 0.66 0.44 120.9 ± 14.8 121.0 ± 17.6 128.1 ± 18.9 0.36 0.51
DBP (mmHg)†† 75.4 ± 10.1 75.9 ± 8.7 76.4 ± 8.6 0.14 0.09 75.7 ± 9.0 75.7 ± 10.1 78.1 ± 12.2 0.56 0.58
  1. Data are expressed as the mean ± SD. SBP: systolic blood pressure, DBP: diastolic blood pressure.
  2. p1: p values were adjusted for age, gender, smoking status and physical activity for anthropometric variables. p values were adjusted for age, gender, BMI, smoking status and physical activity for biological and biochemical variables.
  3. p2: as above and additionally for APOE epsilon status.
  4. *subjects treated for diabetes were excluded (n=54).
  5. subjects treated with lipid-lowering drugs were excluded (n=36).
  6. ††subjects treated for hypertension were excluded (n=89).