Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations

Zeng, Xiao-Na; Yin, Rui-Xing; Huang, Ping; Huang, Ke-Ke; Wu, Jian; Guo, Tao; Lin, Quan-Zhen; Aung, Lynn Htet Htet; Wu, Jin-Zhen; Wang, Yi-Ming

doi:10.1186/1476-511X-12-156

Lipids in Health and Disease

Table 5 Correlation between serum lipid parameters and environmental risk factors in the Mulao and Han populations

From: Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations

Lipid parameter	Risk factor	Unstandardized coefficient	Std. error	Standardized coefficient	t	P
Mulao plus Han
TC	Waist circumference	0.013	0.005	0.091	2.591	0.010
	Age	0.011	0.002	0.138	5.122	0.000
	Alcohol consumption	0.211	0.044	0.126	4.759	0.000
	Body mass index	0.034	0.012	0.095	2.729	0.006
	Diastolic blood pressure	0.007	0.003	0.071	2.564	0.010
TG	Waist circumference	0.063	0.007	0.235	8.961	0.000
	Alcohol consumption	0.523	0.081	0.169	6.498	0.000
	Blood glucose	0.085	0.035	0.063	2.449	0.014
HDL-C	Waist circumference	−0.010	0.002	−0.161	−5.838	0.000
	Alcohol consumption	0.117	0.023	0.166	5.214	0.000
	Gender	0.127	0.032	0.126	2.958	0.000
	Age	0.003	0.001	0.087	2.957	0.003
	Systolic blood pressure	−0.002	0.001	−0.064	−2.121	0.034
LDL-C	Body mass index	0.049	0.007	0.187	7.152	0.000
	Age	0.010	0.001	0.179	6.837	0.000
	Cigarette smoking	−0.096	0.042	−0.060	−2.279	0.023
ApoA1	Alcohol consumption	0.142	0.015	0.302	9.640	0.000
	Gender	0.104	0.021	0.155	4.947	0.000
	Age	0.001	0.001	0.058	2.215	0.027
ApoB	Waist circumference	0.007	0.002	0.141	3.963	0.000
	Nation	−0.120	0.021	−0.148	−5.689	0.000
	Gender	−0.074	0.022	−0.091	−3.412	0.000
	Blood glucose	0.022	0.006	0.089	3.373	0.004
	Body mass index	0.010	0.004	0.082	2.360	0.011
ApoA1/ApoB	Waist circumference	−0.009	0.004	−0.094	−2.594	0.010
	Blood glucose	−0.038	0.013	−0.078	−2.906	0.004
	Gender	0.212	0.050	0.134	4.204	0.000
	Alcohol consumption	0.112	0.035	0.100	3.190	0.001
	Body mass index	−0.025	0.008	−0.105	−2.984	0.003
Mulao
TC	Body mass index	0.075	0.017	0.169	4.395	0.000
	Age	0.011	0.003	0.123	3.204	0.001
	Alcohol consumption	0.194	0.070	0.107	2.791	0.005
TG	Waist circumference	0.061	0.011	0.212	5.596	0.000
	Alcohol consumption	0.598	0.124	0.183	4.830	0.000
HDL-C	Body mass index	−0.036	0.006	−0.230	−6.053	0.000
	Alcohol consumption	0.111	0.029	0.175	3.793	0.000
	Gender	0.120	0.044	0.127	2.755	0.006
LDL-C	Body mass index	0.053	0.011	0.177	4.625	0.000
	Age	0.008	0.002	0.137	3.577	0.000
	Alcohol consumption	−0.132	0.046	−0.109	−2.846	0.005
ApoA1	Alcohol consumption	0.146	0.025	0.268	5.766	0.000
	Gender	0.122	0.038	0.150	3.226	0.001
	Pulse pressure	0.002	0.001	0.086	2.252	0.025
ApoB	Waist circumference	0.013	0.002	0.198	5.143	0.000
ApoA1/ApoB	Waist circumference	−0.018	0.005	−0.144	−3.692	0.000
	Blood glucose	−0.051	0.025	−0.080	−2.051	0.041
Han
TC	Diastolic blood pressure	0.016	0.003	0.178	4.783	0.000
	Alcohol consumption	0.253	0.054	0.168	4.699	0.000
	Age	0.010	0.002	0.153	4.159	0.000
	Body mass index	0.043	0.010	0.150	4.143	0.000
TG	Waist circumference	0.058	0.009	0.231	6.404	0.000
	Cigarette smoking	0.638	0.124	0.178	5.140	0.000
	Blood glucose	0.218	0.043	0.184	5.086	0.000
	Diastolic blood pressure	0.029	0.006	0.167	4.559	0.000
	Age	−0.017	0.005	−0.130	−3.514	0.000
HDL-C	Waist circumference	−0.009	0.003	−0.137	−3.629	0.000
	Gender	0.158	0.046	0.148	3.416	0.001
	Alcohol consumption	0.105	0.034	0.134	3.099	0.002
LDL-C	Age	0.012	0.002	0.216	6.053	0.000
	Body mass index	0.047	0.008	0.203	5.620	0.000
	Cigarette smoking	−0.267	0.068	−0.176	−3.916	0.000
	Gender	−0.230	0.075	−0.140	−3.086	0.002
ApoA1	Alcohol consumption	0.128	0.016	0.340	7.839	0.000
	Gender	0.107	0.024	0.211	4.478	0.000
	Body mass index	−0.007	0.003	−0.097	−2.695	0.007
	Cigarette smoking	0.056	0.022	0.119	2.558	0.011
ApoB	Waist circumference	0.004	0.001	0.179	4.262	0.000
	Alcohol consumption	0.054	0.010	0.187	5.631	0.000
	Blood glucose	0.020	0.004	0.167	5.018	0.000
	Body mass index	0.011	0.002	0.195	4.746	0.000
	Diastolic blood pressure	−0.002	0.001	−0.099	−2.314	0.021
ApoA1/ApoB	Body mass index	−0.024	0.006	−0.186	−4.256	0.000
	Diastolic blood pressure	−0.003	0.001	−0.132	−3.733	0.000
	Waist circumference	−0.008	0.003	−0.134	−3.045	0.002
	Gender	0.239	0.043	0.256	5.521	0.000
	Cigarette smoking	0.151	0.039	0.176	3.886	0.000
	Alcohol consumption	0.071	0.029	0.103	2.436	0.015

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/Apo B, the ratio of apolipoprotein A1 to apolipoprotein B. The correlation was determined by multivariable linear regression analysis with stepwise modeling.

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ISSN: 1476-511X

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