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Table 1 Concentration of AmB (ng/g, Mean +/- SEM) in mouse tissues infected with Candida albicans 7 days after the completion of 5 days oral iCo-010 treatment once daily at 5, 10 and 20 mg/kg doses, (ND; non detectable)

From: Efficacy of an oral and tropically stable lipid-based formulation of Amphotericin B (iCo-010) in an experimental mouse model of systemic candidiasis

Organ AmB concentration (ng/g tissue)
  5 mg/kg (n=15) 10 mg/kg (n=13) 20 mg/kg (n=5)
Kidney    
  123.1 ± 16.4 323.3 ± 51.5 494 ± 79.1*
Liver    
  ND ND ND
Spleen    
  114.5 ± 26.7 202.5 ± 15.6 266.5 ± 29*
Lung    
  ND 46.2 ± 1.4 78.2 ± 7.5
Heart    
  ND 45 ± 11.6 121.4 ± 50.7
Brain    
  ND ND ND
  1. *p<0.05 significantly different from the 5 mg/kg treatment group.