Table 1 Concentration of AmB (ng/g, Mean +/- SEM) in mouse tissues infected with Candida albicans 7 days after the completion of 5 days oral iCo-010 treatment once daily at 5, 10 and 20 mg/kg doses, (ND; non detectable)
Organ | AmB concentration (ng/g tissue) | ||
|---|---|---|---|
5 mg/kg (n=15) | 10 mg/kg (n=13) | 20 mg/kg (n=5) | |
Kidney | |||
123.1 ± 16.4 | 323.3 ± 51.5 | 494 ± 79.1* | |
Liver | |||
ND | ND | ND | |
Spleen | |||
114.5 ± 26.7 | 202.5 ± 15.6 | 266.5 ± 29* | |
Lung | |||
ND | 46.2 ± 1.4 | 78.2 ± 7.5 | |
Heart | |||
ND | 45 ± 11.6 | 121.4 ± 50.7 | |
Brain | |||
ND | ND | ND | |