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Table 4 Changes seen in the survival, FR generated, and LXA 4 , TNF-α and IL-6 secreted by RWPE-1 cells when supplemented with different doses of fatty acids for 48 hours

From: Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro

Treatment RWPE-1% survival FR generated % of control LXA4levels % of control IL-6% of control TNF-α % of control
Control 100 ± 3.49 100 ± 5.40 100 ± 0.43 100 ± 0.74 100 ± 6.43
LA 50 μM 94.74 ± 7.01* 104.61 ± 10.00* 48.75 ± 10.46*** 86.96 ± 11.94** 165.71 ± 8.60***
LA 150 μM 73.68 ± 3.58** 84.00 ± 7.38** 67.96 ± 4.53** 82.12 ± 11.94** 114.28 ± 10.77**
GLA 25 μM 98.39 ± 2.94* 50.66 ± 4.80*** 49.91 ± 0.70*** 18.70 ± 0.42*** 57.03 ± 7.18***
GLA 50 μM 108.64 ± 7.30* 64.14 ± 5.10*** 71.43 ± 0.79** 31.32 ± 0.51*** 53.91 ± 7.47***
GLA 75 μM 85.25 ± 4.95** 78.71 ± 2.77** 80.65 ± 2.17** 42.92 ± 1.17*** 89.01 ± 0.97**
AA 50 μM 106.46 ± 0.69* 71.89 ± 2.17** 60.18 ± 0.79*** 99.42 ± 0.30 66.16 ± 0.94**
AA 100 μM 41.92 ± 3.93*** 69.03 ± 5.77** 179.05 ± 1.95*** 99.78 ± 0.23 64.73 ± 1.83**
ALA 50 μM 90.91 ± 7.35* 80.00 ± 7.34** 37.04 ± 6.00*** 114.28 ± 7.49* 178.57 ± 2.85***
ALA150μM 59.09 ± 5.44** 100.23 ± 8.08 70.37 ± 6.00** 130.95 ± 6.43** 149.28 ± 5.77**
EPA 50 μM 108.2 ± 7.74* 60.60 ± 6.50*** 67.00 ± 1.15** 97.30 ± 0.57 47.69 ± 3.03***
EPA 100 μM 82.61 ± 7.85** 39.47 ± 4.32*** 41.69 ± 0.64*** 102.22 ± 0.93 35.47 ± 6.16***
DHA 50 μM 96.47 ± 9.31* 75.69 ± 5.70** 46.42 ± 1.06*** 99.60 ± 0.44 44.74 ± 3.31***
DHA100μM 85.71 ± 3.97** 74.74 ± 6.44** 51.95 ± 1.69*** 111.70 ± 2.09* 54.73 ± 5.25***
  1. *P < 0.05, **P < 0.01, ***P < 0.001 compared to control.