Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

Wang, Chunhua; Cui, Yizhe; Li, Chunyan; Zhang, Yanhua; Xu, Shang; Li, Xiaochong; Li, Hong; Zhang, Xiuying

doi:10.1186/1476-511X-12-165

Lipids in Health and Disease

Table 1 The fatty acid content and ratios in the mice liver

From: Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

Fatty acid	WT-control	WT-HFD	Nrf2-null-control	Nrf2-null-HFD
C12: 0	0.07 ± 0.01	0.07 ± 0.01	0.07 ± 0.01	0.08 ± 0.01**
C14: 0	0.14 ± 0.01	0.13 ± 0.01	0.22 ± 0.02$$	0.19 ± 0.02$$
C15: 0	0.12 ± 0.01	0.13 ± 0.01	0.12 ± 0.01	0.14 ± 0.01*
C16: 0	5.64 ± 0.48	10.56 ± 0.78**	5.98 ± 0.54	11.59 ± 0.95**
C17: 0	0.07 ± 0.01	0.11 ± 0.01**	0.08 ± 0.01	0.12 ± 0.01**
C18: 0	4.17 ± 0.28	5.10 ± 0.41*	4.30 ± 0.37	5.46 ± 0.49*
C18: 1	7.46 ± 0.64	13.35 ± 1.16**	7.66 ± 0.67	17.40 ± 1.36**$$
c18: 2	5.13 ± 0.39	7.34 ± 0.59**	5.30 ± 0.39	8.13 ± 0.68**
C18: 3	0.03 ± 0.00	0.03 ± 0.00	0.03 ± 0.00	0.04 ± 0.00*
C20: 0	0.08 ± 0.01	0.10 ± 0.01	0.09 ± 0.01	0.15 ± 0.01**$$
C20: 1	0.08 ± 0.01	0.10 ± 0.01**	0.08 ± 0.01	0.12 ± 0.01**$
C20: 2	0.18 ± 0.01	0.31 ± 0.03**	0.19 ± 0.02	0.32 ± 0.03**
C20: 3	0.29 ± 0.03	0.38 ± 0.03**	0.30 ± 0.03	0.40 ± 0.03**
C20: 4	2.55 ± 0.21	3.26 ± 0.31**	2.74 ± 0.03	3.46 ± 0.32*
C22: 0	0.02 ± 0.00	0.03 ± 0.01*	0.03 ± 0.00	0.05 ± 0.01**$$
C22: 6	0.85 ± 0.06	0.57 ± 0.03**	0.68 ± 0.05	0.64 ± 0.05
TFA	26.88 ± 2.17	41.57 ± 3.41**	27.87 ± 2.38	48.31 ± 3.99**$
SFA	10.32 ± 0.75	16.23 ± 1.18**	10.89 ± 0.91	17.79 ± 1.44**
UFA	16.56 ± 0.91	25.34 ± 1.56**	16.98 ± 1.28	30.51 ± 2.30**$
PUFA	9.03 ± 0.36	11.90 ± 0.49**	9.25 ± 0.63	12.99 ± 0.98**
MUFA	7.53 ± 0.63	13.45 ± 1.15**	7.73 ± 0.68	17.52 ± 1.36**$$
SFA/TFA ratio (%)	38.37 ± 0.57	39.08 ± 0.37	39.24 ± 0.54	36.83 ±0.36**$$
UFA/TFA ratio (%)	61.62 ± 0.57	60.97 ± 0.37	60.93 ± 0.54	63.16 ± 0.36**$$
PUFA/SFA ratio (%)	87.69 ± 4.63	73.45 ± 3.39**	85.05 ± 3.57	73.07 ± 2.42**
MUFA/SFA ratio (%)	72.99 ± 0.83	82.80 ± 1.11**	71.02 ± 0.34	98.48 ± 0.34**$$
n-6 / n-6 ratio (%)	49.94 ± 6.59	43.49 ± 5.78	50.47 ± 2.98$$	42.65 ± 3.89*

Asterisks * represent statistical difference caused by HFD within WT and null-Nrf2 groups; dollar signs $ represent statistical difference from WT and null-Nrf2 on the same diet. 0.05 < P values < 0.01 (*, $). P values < 0.01 (**, $$).
All of the values are expressed as mean ± standard deviation (SD) (n = 20 per treatment group). TFA, total fatty acid; SFA, saturated fatty acid; UFA, unsaturated fatty acid; PUFA, polyunsaturated fatty acid; MUFA, monounsaturated fatty acid; n-6/n-6 ratio, C20: 4/C18: 2.

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ISSN: 1476-511X

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