Skip to main content

Advertisement

Table 1 The fatty acid content and ratios in the mice liver

From: Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

Fatty acid WT-control WT-HFD Nrf2-null-control Nrf2-null-HFD
C12: 0 0.07 ± 0.01 0.07 ± 0.01 0.07 ± 0.01 0.08 ± 0.01**
C14: 0 0.14 ± 0.01 0.13 ± 0.01 0.22 ± 0.02$$ 0.19 ± 0.02$$
C15: 0 0.12 ± 0.01 0.13 ± 0.01 0.12 ± 0.01 0.14 ± 0.01*
C16: 0 5.64 ± 0.48 10.56 ± 0.78** 5.98 ± 0.54 11.59 ± 0.95**
C17: 0 0.07 ± 0.01 0.11 ± 0.01** 0.08 ± 0.01 0.12 ± 0.01**
C18: 0 4.17 ± 0.28 5.10 ± 0.41* 4.30 ± 0.37 5.46 ± 0.49*
C18: 1 7.46 ± 0.64 13.35 ± 1.16** 7.66 ± 0.67 17.40 ± 1.36**$$
c18: 2 5.13 ± 0.39 7.34 ± 0.59** 5.30 ± 0.39 8.13 ± 0.68**
C18: 3 0.03 ± 0.00 0.03 ± 0.00 0.03 ± 0.00 0.04 ± 0.00*
C20: 0 0.08 ± 0.01 0.10 ± 0.01 0.09 ± 0.01 0.15 ± 0.01**$$
C20: 1 0.08 ± 0.01 0.10 ± 0.01** 0.08 ± 0.01 0.12 ± 0.01**$
C20: 2 0.18 ± 0.01 0.31 ± 0.03** 0.19 ± 0.02 0.32 ± 0.03**
C20: 3 0.29 ± 0.03 0.38 ± 0.03** 0.30 ± 0.03 0.40 ± 0.03**
C20: 4 2.55 ± 0.21 3.26 ± 0.31** 2.74 ± 0.03 3.46 ± 0.32*
C22: 0 0.02 ± 0.00 0.03 ± 0.01* 0.03 ± 0.00 0.05 ± 0.01**$$
C22: 6 0.85 ± 0.06 0.57 ± 0.03** 0.68 ± 0.05 0.64 ± 0.05
TFA 26.88 ± 2.17 41.57 ± 3.41** 27.87 ± 2.38 48.31 ± 3.99**$
SFA 10.32 ± 0.75 16.23 ± 1.18** 10.89 ± 0.91 17.79 ± 1.44**
UFA 16.56 ± 0.91 25.34 ± 1.56** 16.98 ± 1.28 30.51 ± 2.30**$
PUFA 9.03 ± 0.36 11.90 ± 0.49** 9.25 ± 0.63 12.99 ± 0.98**
MUFA 7.53 ± 0.63 13.45 ± 1.15** 7.73 ± 0.68 17.52 ± 1.36**$$
SFA/TFA ratio (%) 38.37 ± 0.57 39.08 ± 0.37 39.24 ± 0.54 36.83 ±0.36**$$
UFA/TFA ratio (%) 61.62 ± 0.57 60.97 ± 0.37 60.93 ± 0.54 63.16 ± 0.36**$$
PUFA/SFA ratio (%) 87.69 ± 4.63 73.45 ± 3.39** 85.05 ± 3.57 73.07 ± 2.42**
MUFA/SFA ratio (%) 72.99 ± 0.83 82.80 ± 1.11** 71.02 ± 0.34 98.48 ± 0.34**$$
n-6 / n-6 ratio (%) 49.94 ± 6.59 43.49 ± 5.78 50.47 ± 2.98$$ 42.65 ± 3.89*
  1. Asterisks * represent statistical difference caused by HFD within WT and null-Nrf2 groups; dollar signs $ represent statistical difference from WT and null-Nrf2 on the same diet. 0.05 < P values < 0.01 (*, $). P values < 0.01 (**, $$).
  2. All of the values are expressed as mean ± standard deviation (SD) (n = 20 per treatment group). TFA, total fatty acid; SFA, saturated fatty acid; UFA, unsaturated fatty acid; PUFA, polyunsaturated fatty acid; MUFA, monounsaturated fatty acid; n-6/n-6 ratio, C20: 4/C18: 2.