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Table 4 Analysis of polyunsaturated fatty acids before and after insulin analog initiation therapy

From: LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy

Parameter

Before treatment (mean ± SD)

After treatment (mean ± SD)

n

p value

DGLA (C20:3n6) (μg/ml)

44.11 ± 13.97

60.84 ± 10.72*

16

<0.001

AA (C20:4n6) (μg/ml)

100.10 ± 23.28

117.65 ± 24.66*

16

0.018

EPA (C20:5n3) (μg/ml)

3.98 ± 3.09

5.07 ± 2.25*

16

0.004

DHA (C22:6n3) (μg/ml)

31.33 ± 13.31

38.16 ± 11.66 *

16

<0.001

AA/DHA

3.47 ± 1.08

3.23 ± 0.77

16

0.065

AA/EPA

31.28 ± 11.76

25.34 ± 7.88*

16

0.006

  1. DGLA, Dihomo-gamma-linolenic acid; AA, Arachidonic acid; EPA, Eicosapentaenoic acid; DHA, Docosahexaenoic acid.