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Figure 4 | Lipids in Health and Disease

Figure 4

From: Reduced beta2-glycoprotein I protects macrophages from ox-LDL-induced foam cell formation and cell apoptosis

Figure 4

The expression of CD36, SRB1, ABCA1, and ABCG1 mRNAs in macrophages (compared with control). RAW264.7 macrophages were seeded onto 96-well microtitre plates and supplemented with ox-LDL alone or along with beta2-GPI or reduced beta2-GPI. Real-time PCR was used to detect the mRNA levels of CD36, SRB1, ABCA1, and ABCG1. β-actin was selected as the internal control. Ox-LDL increased the expression of CD36 and ABCA1 mRNAs. Both beta2-GPI and reduced beta2-GPI inhibited the ox-LDL-induced expression of CD36 mRNA, and there was also a significant difference between the two groups. In addition, reduced beta2-GPI inhibited the ox-LDL-induced expression of ABCA1 mRNA. Note: n = 3, *: compared with the control group, p < 0.01; ▲: compared with the ox-LDL group, p < 0.05; ▲▲: compared with the ox-LDL group, p < 0.01; #: compared with the beta2-GPI group, p < 0.05.

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Lipids in Health and Disease

ISSN: 1476-511X