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Table 2 mRNA expressions of ABCA1, SR-BI, ABCG1, LXRα and PPARγ in liver

From: The combination of L-4F and simvastatin stimulate cholesterol efflux and related proteins expressions to reduce atherosclerotic lesions in apoE knockout mice

  ABCA1 SR-BI ABCG1 LXRα PPARγ
W-T group 12 12 12 12 12
AS group 0.52 ± 0.08 0.64 ± 0.06 0.75 ± 0.12 0.40 ± 0.07 0.50 ± 0.08
Simva group 0.98 ± 0.14 2 0.69 ± 0.11 1.23 ± 0.192 0.71 ± 0.072 0.96 ± 0.072
L-4F group 1.38 ± 0.12 2b 1.01 ± 0.142b 1.46 ± 0.162b 1.08 ± 0.102b 1.19 ± 0.202b
Simva + L-4F 1.51 ± 0.13 2b 1.96 ± 0.492** 1.73 ± 0.242b** 1.31 ± 0.202b** 1.52 ± 0.102b**
  1. 1P < 0.05, 2P < 0.001, vs. AS group; aP < 0.05, bP < 0.001, vs. Simva group.
  2. *P < 0.05, **P < 0.001, vs. L-4F group.