Table 2 Effect of SCARB1 gene exon 8 SNP rs5888 on serum lipid profile in human populations

White Americans with Coronary artery disease (n = 371);

No associations with lipid levels.

McCarthy et al.; 2003[17]

Age of 45 yrs and older

White Americans – Amish population (n = 919). Age of 18 yrs and older.

↑HDL-Chol levels in women less than 50 years.

Roberts et al.; 2007[22]

No associations with lipid concentrations in men.

White Caucasians - population of Geneva, Switzerland (n = 1756). Aged 35–74 yrs.

↑ HDL-Chol level and HDL-Chol/LDL-Chol ratio in men CT + TT vs CC carriers aged 55–74 yrs.

Morabia et al.; 2004[19]

Postmenopausal Caucasian women (n = 689)

↑HDL-Chol among estrogen users.

Richard et al.; 2005[20]

North Americans/Framingham, USA (n = 2650).

↑HDL-Chol, ↓LDL-Chol.

Osgood et al.; 2003[18]

Aged 26–79 yrs.

Associated with an ↑ in HDL particle diameter in both men and women.

Healthy white Europeans – Spanish population (n = 489).

↓LDL-Chol in women.

Acton et al.; 1999[16]

Mean age: women 36 ± 12 yrs; in men 39 ± 19 yrs.

No associations with lipids concentration in men

Hypercholesterolemic and normolipidemic Brasilian individuals (n = 332).

No relation with lipid levels.

Cerda et al.; 2010[15]

Aged 29–81 yrs.

↑ response to atorvastatin in women.

Canarian/Spanish population (n = 619).

No association with lipid levels.

Rodriguez-Esparragon et al.; 2005[21]

Aged 25 to 79 yrs.

↓Coronary heart disease risk for men.

Healthy Spanish men population (n = 59).

No difference in fasting lipid concentrations by genotype.

Tanaka et al.; 2007[23]

Aged 18–49 yrs.

↓ postprandial TG response in the smaller, partially catabolized lipoprotein fraction reflects an antiatherogenic phenotype.

Two Chinese populations: Guangxi Bai Ku Yao, Han (n = 1183).

↓HDL-Chol than in CC or CT carriers.

Wu et al.; 2012[27]

Aged 16 to 80 yrs.

Two Chinese populations: Mulao, Han (n = 1608).

↓HDL-Chol in Mulao females compared with CC or CT carriers;

Wu et al.; 2012[28]

Aged 16 to 86 yrs.

↓HDL-Chol in Han males compared with CC subjects;

↑TG in Han subjects compared to CC or CT.