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Table 1 TQ supplementation improves materno-fetal parameters and neonatal outcome of pregnant diabetic dams

From: Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling

 

Control dams

Diabetic dams

Diabetic dams supplemented with TQ

Parameters

   

Total pregnancies

15

13

14

Successful pregnancies

14

9

12

Abortion (%)

6.66

31

14

Total neonates

121

64

96

Alive pups at four weeks

115

48

85

Dead pups

6

16

11

Mortality (%)

4.96

25

11.46

Blood glucose (mg/dl)

Before pregnancy

3d after vehicle or STZ injection

178 ± 14.5

265 ± 19.7*

259 ± 17.4+

During pregnancy

1st W

193 ± 17.1

283 ± 21*

247 ± 23#+

 

2nd W

203 ± 18.7

311 ± 23.5*

257 ± 16.9#+

 

3rd W

187 ± 12.4

342 ± 28*

266 ± 23.5#+

 

After pregnancy

7d postpartum

179 ± 12.5

295 ± 28.4*

246 ± 19.3#+

  1. The results are expressed as the mean ± SEM. *P < 0.05 for diabetic vs. control; #P < 0.05 for diabetic + TQ vs. diabetic; +P < 0.05 for diabetic + TQ vs. control.
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Lipids in Health and Disease

ISSN: 1476-511X