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Table 1 TQ supplementation improves materno-fetal parameters and neonatal outcome of pregnant diabetic dams

From: Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling

  Control dams Diabetic dams Diabetic dams supplemented with TQ
Parameters    
Total pregnancies 15 13 14
Successful pregnancies 14 9 12
Abortion (%) 6.66 31 14
Total neonates 121 64 96
Alive pups at four weeks 115 48 85
Dead pups 6 16 11
Mortality (%) 4.96 25 11.46
Blood glucose (mg/dl) Before pregnancy 3d after vehicle or STZ injection 178 ± 14.5 265 ± 19.7* 259 ± 17.4+
During pregnancy 1st W 193 ± 17.1 283 ± 21* 247 ± 23#+
  2nd W 203 ± 18.7 311 ± 23.5* 257 ± 16.9#+
  3rd W 187 ± 12.4 342 ± 28* 266 ± 23.5#+
  After pregnancy 7d postpartum 179 ± 12.5 295 ± 28.4* 246 ± 19.3#+
  1. The results are expressed as the mean ± SEM. *P < 0.05 for diabetic vs. control; #P < 0.05 for diabetic + TQ vs. diabetic; +P < 0.05 for diabetic + TQ vs. control.