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Table 2 Significant alterations in body weight, insulin level, lymphocyte counts, and levels of free radicals in offspring at 8 weeks of age

From: Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling

Parameters Offspring of control dams Offspring of diabetic dams Offspring of diabetic dams supplemented with TQ
At birth
Body weight (g) 1.24 ± 0.1 1.89 ± 0.1* 1.39 ± 0.11#
At age of 8 weeks
body weight (g) 20 ± 1.9 28.9 ± 2.9* 23.3 ± 2.3
Blood glucose (mg/dl) 141 ± 12 218 ± 19.5* 178.5 ± 13.4#+
Insulin (ng/ml) 2.4 ± 0.1 1.52 ± 0.15* 2.1 ± 0.19#
WBCs count (103/ul) 15 ± 0.9 11 ± 0.1* 13.5 ± 0.18#
Lymphocytes (%) 75 ± 5.8 58 ± 4.8* 71.6 ± 0.18#
Monocytes (%) 5 ± 0.18 4 ± 0.35 5 ± 0.6
Neutrophils (%) 20 ± 1.45 19 ± 1.3 21 ± 1.95
ROS (nmol/ml) 11 ± 1.9 25 ± 3.9* 17 ± 2.1#+
Hydroperoxide (mg/100 ml) 17 ± 2.7 34 ± 4.4* 24 ± 2.8#+
  1. The results are expressed as the mean ± SEM. *P < 0.05 for diabetic vs. control; #P < 0.05 for diabetic + TQ vs. diabetic; +P < 0.05 for diabetic + TQ vs. control.