Table 2 Relationships between genotypes/haplotypes of the SIRT1 gene and metabolic phenotypes
Genotype | Total-Cholesterol | LDL-Cholesterol | HDL-Cholesterol | Triglycerides* | Glucose* | HbA1c | BMI** | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | (mg/dl) | n | (mg/dl) | n | (mg/dl) | n | (mg/dl) | n | (mg/dl) | n | (%) | n | (kg/m2) | ||
Male | |||||||||||||||
rs7069102 | CC | 487 | 208.9 ± 31.4 | 482 | 129.4 ± 29.1 | 487 | 57.5 ± 16.7 | 487 | 135.2 ± 105.4 | 487 | 99.7 ± 15.7 | 484 | 5.27 ± 0.60 | 487 | 23.5 ± 2.8 |
(intron 4) | CG | 207 | 212.7 ± 31.4 | 203 | 133.5 ± 31.0 | 207 | 55.5 ± 15.3 | 207 | 146.0 ± 97.3 | 207 | 99.2 ± 14.8 | 206 | 5.29 ± 0.58 | 207 | 23.4 ± 2.9 |
GG | 13 | 203.8 ± 31.8 | 13 | 122.7 ± 34.3 | 13 | 60.6 ± 13.7 | 13 | 100.8 ± 55.5 | 13 | 93.5 ± 12.1 | 13 | 5.33 ± 0.61 | 13 | 24.1 ± 7.1 | |
P value | 0.067 | 0.010 | 0.42 | 0.017 | 0.31 | 0.46 | 0.55 | ||||||||
rs2273773 | TT | 315 | 212.4 ± 33.2 | 311 | 134.4 ± 30.6 | 315 | 55.3 ± 15.7 | 315 | 136.4 ± 103.1 | 315 | 99.2 ± 14.8 | 313 | 5.29 ± 0.58 | 315 | 23.4 ± 2.9 |
(exon 5) | TC | 294 | 208.8 ± 29.6 | 290 | 127.1 ± 28.5 | 294 | 58.1 ± 16.4 | 294 | 140.2 ± 106.8 | 294 | 99.8 ± 16.9 | 293 | 5.25 ± 0.64 | 294 | 23.5 ± 2.9 |
CC | 98 | 207.8 ± 30.4 | 97 | 127.7 ± 30.0 | 98 | 58.9 ± 17.5 | 98 | 134.7 ± 87.3 | 98 | 99.5 ± 12.2 | 97 | 5.31 ± 0.47 | 98 | 23.7 ± 2.8 | |
P value | 0.32 | 0.024 | 0.054 | 0.86 | 0.71 | 0.81 | 0.40 | ||||||||
rs3818292 | AA | 313 | 212.4 ± 33.4 | 309 | 134.3 ± 30.6 | 313 | 55.4 ± 15.6 | 313 | 136.1 ± 103.7 | 313 | 99.4 ± 14.8 | 311 | 5.29 ± 0.59 | 313 | 23.4 ± 2.9 |
(intron 5) | AG | 297 | 208.0 ± 29.4 | 293 | 127.3 ± 28.4 | 297 | 57.9 ± 16.4 | 297 | 140.6 ± 106.0 | 297 | 99.7 ± 16.9 | 296 | 5.26 ± 0.64 | 297 | 23.5 ± 3.0 |
GG | 97 | 207.8 ± 30.7 | 96 | 127.7 ± 30.2 | 97 | 59.1 ± 17.8 | 97 | 134.4 ± 87.7 | 97 | 99.0 ± 12.0 | 96 | 5.31 ± 0.46 | 97 | 23.7 ± 2.7 | |
P value | 0.27 | 0.024 | 0.10 | 0.70 | 0.75 | 0.85 | 0.34 | ||||||||
haplotype 1 | + | 515 | 210.6 ± 32.4 | 510 | 131.6 ± 30.1 | 515 | 56.6 ± 16.2 | 515 | 135.7 ± 102.2 | 515 | 99.9 ± 16.5 | 513 | 5.28 ± 0.63 | 515 | 23.5 ± 2.8 |
(C-T-A) | - | 192 | 208.1 ± 28.6 | 188 | 127.2 ± 28.7 | 192 | 58.0 ±16.6 | 192 | 143.2 ± 103.5 | 192 | 98.2 ± 11.6 | 190 | 5.28 ± 0.48 | 192 | 23.5 ± 3.2 |
P value | 0.53 | 0.150 | 0.24 | 0.21 | 0.34 | 0.59 | 0.86 | ||||||||
haplotype 2 | + | 384 | 208.0 ± 29.7 | 379 | 127.4 ± 28.8 | 384 | 58.1 ± 16.7 | 384 | 139.8 ± 102.8 | 384 | 99.7 ± 16.0 | 382 | 5.27 ± 0.60 | 384 | 23.5 ± 2.7 |
(C-C-G) | - | 323 | 212.2 ± 33.2 | 319 | 134.1 ± 30.5 | 323 | 55.6 ± 15.7 | 323 | 135.3 ± 102.3 | 323 | 99.2 ± 14.7 | 321 | 5.29 ± 0.58 | 323 | 23.5 ± 3.2 |
P value | 0.17 | 0.011 | 0.049 | 0.47 | 0.60 | 0.68 | 0.14 | ||||||||
haplotype 3 | + | 213 | 212.5 ± 31.6 | 209 | 133.2 ± 31.3 | 213 | 55.5 ± 14.9 | 231 | 144.4 ± 97.1 | 213 | 99.1 ± 14.8 | 212 | 5.30 ± 0.59 | 213 | 22.4 ± 3.2 |
(G-T-A) | - | 494 | 208.8 ± 31.3 | 489 | 129.2 ± 29.1 | 494 | 57.6 ± 16.8 | 494 | 134.9 ± 104.8 | 494 | 99.6 ± 15.6 | 491 | 5.27 ± 0.59 | 494 | 23.5 ± 2.8 |
P value | 0.069 | 0.055 | 0.31 | 0.053 | 0.57 | 0.37 | 0.51 | ||||||||
Female | |||||||||||||||
rs7069102 | CC | 504 | 217.7 ± 31.9 | 492 | 131.7 ± 30.9 | 504 | 71.6 ± 17.2 | 504 | 85.7 ± 43.2 | 504 | 92.9 ± 11.3 | 493 | 5.14 ± 0.45 | 504 | 22.2 ± 3.2 |
(intron 4) | CG | 198 | 217.9 ± 30.2 | 190 | 132.0 ± 28.0 | 198 | 71.8 ± 17.0 | 198 | 87.8 ± 50.2 | 198 | 92.0 ± 9.0 | 192 | 5.16 ± 0.40 | 198 | 22.1 ± 2.9 |
GG | 21 | 215.0 ± 31.1 | 20 | 134.4 ± 26.3 | 21 | 63.6 ± 15.9 | 21 | 102.8 ± 59.6 | 21 | 94.3 ± 17.7 | 20 | 5.11 ± 0.44 | 21 | 22.7 ± 2.8 | |
P value | 0.63 | 0.82 | 0.12 | 0.13 | 0.75 | 0.20 | 0.50 | ||||||||
rs2273773 | TT | 310 | 218.6 ± 32.0 | 300 | 134.0 ±30.8 | 310 | 70.0 ± 16.8 | 310 | 89.9 ± 49.3 | 310 | 93.3 ± 12.9 | 301 | 5.17 ± 0.50 | 310 | 22.2 ± 3.0 |
(exon 5) | TC | 320 | 215.6 ± 31.0 | 315 | 129.0 ± 29.7 | 320 | 72.5 ± 17.2 | 320 | 83.5 ± 40.8 | 320 | 91.8 ± 8.9 | 316 | 5.12 ± 0.37 | 320 | 22.1 ± 3.1 |
CC | 93 | 221.7 ± 30.4 | 87 | 135.0 ± 27.3 | 93 | 72.8 ± 17.7 | 93 | 87.6 ± 49.4 | 93 | 93.4 ±10.0 | 88 | 5.15 ± 0.44 | 93 | 22.6 ± 3.4 | |
P value | 0.23 | 0.091 | 0.096 | 0.25 | 0.14 | 0.70 | 0.66 | ||||||||
rs3818292 | AA | 303 | 219.1 ± 31.9 | 294 | 134.4 ± 30.4 | 303 | 69.8 ± 16.9 | 303 | 90.3 ± 49.1 | 303 | 93.5 ± 13.0 | 295 | 5.17 ± 0.50 | 303 | 22.2 ± 3.0 |
(intron 5) | AG | 309 | 214.9 ± 30.8 | 305 | 128.7 ± 30.1 | 309 | 72.4 ± 17.0 | 309 | 83.3 ± 41.4 | 309 | 91.7 ± 9.1 | 305 | 5.12 ± 0.37 | 309 | 22.1 ± 3.2 |
GG | 111 | 221.8 ± 30.9 | 103 | 133.8 ± 27.9 | 111 | 73.4 ± 17.8 | 111 | 86.8 ± 47.6 | 111 | 93.2 ± 9.2 | 105 | 5.13 ± 0.42 | 111 | 22.5 ± 3.30 | |
P value | 0.11 | 0.061 | 0.047 | 0.17 | 0.090 | 0.94 | 0.83 | ||||||||
haplotype 1 | + | 515 | 216.9 ± 31.8 | 504 | 131.7 ± 31.1 | 515 | 70.8 ± 16.8 | 515 | 86.6 ± 44.2 | 515 | 92.7 ± 11.1 | 505 | 5.14 ± 0.45 | 515 | 22.1 ± 3.1 |
(C-T-A) | - | 208 | 219.7 ± 30.1 | 198 | 132.2 ± 26.9 | 208 | 73.2 ± 17.7 | 208 | 87.2 ± 49.6 | 208 | 92.7 ± 10.5 | 200 | 5.14 ± 0.41 | 208 | 22.3 ± 3.1 |
P value | 0.47 | 0.77 | 0.045 | 0.65 | 0.70 | 0.43 | 0.88 | ||||||||
haplotype 2 | + | 408 | 216.9 ± 31.0 | 397 | 130.1 ± 29.4 | 408 | 72.6 ± 17.2 | 408 | 84.5 ± 43.0 | 408 | 92.1 ± 9.1 | 399 | 5.13 ± 0.38 | 408 | 22.2 ± 3.2 |
(C-C-G) | - | 315 | 218.7 ± 31.9 | 305 | 134.1 ± 30.6 | 315 | 69.9 ± 16.9 | 315 | 89.7 ± 49.0 | 315 | 93.4 ± 12.9 | 306 | 5.16 ± 0.50 | 315 | 22.2 ± 3.0 |
P value | 0.27 | 0.039 | 0.065 | 0.16 | 0.088 | 0.85 | 0.95 | ||||||||
haplotype 3 | + | 216 | 217.5 ± 30.4 | 208 | 132.4 ± 28.0 | 216 | 71.0 ± 17.1 | 216 | 88.9 ± 51.5 | 216 | 92.2 ± 10.2 | 209 | 5.15 ± 0.41 | 216 | 22.2 ± 2.9 |
(G-T-A) | - | 507 | 217.8 ± 31.8 | 494 | 131.6 ± 30.8 | 507 | 71.7 ± 17.1 | 507 | 85.8 ± 43.1 | 507 | 92.9 ± 11.2 | 496 | 5.14 ± 0.45 | 507 | 22.2 ± 3.2 |
P value | 0.96 | 0.67 | 0.47 | 0.22 | 0.92 | 0.29 | 0.72 | ||||||||