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Figure 1 | Lipids in Health and Disease

Figure 1

From: C-reactive protein/oxidised low-density lipoprotein/β2-glycoprotein I complex promotes atherosclerosis in diabetic BALB/c mice via p38mitogen-activated protein kinase signal pathway

Figure 1

Body weight of DM group and NC group. ●, DM group (n=120); ■, NC group (n=24). *P < 0.05, compared with group NC. Maintained on high-fat and sugar diet and standard chow diet, respectively, mice in DM group and NC group were weighed every week. Eight weeks later, DM group was intraperitoneally injected with 80 mg/kg 2% STZ three times for three consecutive days. The tail vein blood glucose was measured 72 h after the injection, and those with blood glucose ≥16.7 mmol/L were considered DM mice. The NC group was simultaneously injected with sodium citrate buffer. Two weeks later, the DM group was treated with oxLDL 20 μg, β2GPI 20 μg, oxLDL/β2GPI complex 40 μg, CRP/oxLDL/β2GPI complex 44 μg, and PBS, after which they were randomly divided into oxLDL group, β2GPI group, oxLDL/β2GPI group, CRP/oxLDL/β2GPI group, and PBS group, respectively (each group n=24). The same interventions were boosted four weeks later. NC group were injected with PBS at the same time. Four weeks later, blood was obtained via retro-orbital plexus and then sacrificed by cervical dislocation.

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Lipids in Health and Disease

ISSN: 1476-511X