Figure 1

Macroscopic changes in the skin excisional wound sites that determine wound closure. (A) The changes in the percentage of wound closure at each time point after wound injury were measured relative to the original wound area on day 1. The accumulated data on the changes in wound closure from ten individual mice in each group are shown. The data are presented as the mean ± SEM. *P < 0.05, diabetic vs. control; +P < 0.05, diabetic + WP vs. control; #P < 0.05, diabetic + WP vs. diabetic. (B) The hydroxyproline content, which was used as an index of the collagen accumulation at the wound site, was determined. The data are presented as the mean ± SEM. *P < 0.05, diabetic vs. control; +P < 0.05, diabetic + WP vs. control; #P < 0.05, diabetic + WP vs. diabetic.