Table 2 Comparison of selected parameters in patients with DCM from group A (atorvastatin group) and group B (without statin) after 5-year follow-up
PARAMETER | Group A (n = 22) | Group B (n = 23) | p |
|---|---|---|---|
Mean ± SD | Mean ± SD | ||
BMI | 28.9 ± 4.3 | 31.0 ± 4.4 | ns* |
Waist circumference (cm) | 98.3 ± 12.9 | 96.9 ± 13.5 | ns |
Systolic RR (mm Hg) | 114.7 ± 13.0 | 117.5 ± 7.7 | ns |
Diastolic RR (mm Hg) | 71.5 ± 7.7 | 77.3 ± 5.3 | ns |
Heart rate | 77 ± 9 | 69 ± 4 | ns |
Biochemical parameters | |||
White blood cells (*103/μl) | 6.9 ± 1.4 | 7.3 ± 1.4 | ns |
Hemoglobin (g/dl) | 14.6 ± 1.4 | 14.5 ± 1.3 | ns |
Na (mmol/l) | 138 ± 4 | 138 ± 3 | ns |
K (mmol/l) | 4.4 ± 0.4 | 4.5 ± 0.5 | ns |
Total cholesterol (mg/dl) | 178 ± 69 | 202 ± 30 | 0.02 |
HDL cholesterol (mg/dl) | 52 ± 18 | 48 ± 9 | ns |
LDL cholesterol (mg/dl) | 78 ± 25 | 123 ± 27 | 0.001 |
Triglycerides (mg/dl) | 201 ± 212 | 153 ± 37 | ns |
ASPAT (U/l) | 23.6 ± 6.3 | 26.2 ± 9.6 | ns |
ALAT (U/l) | 23.5 ± 7.4 | 26.3 ± 10.7 | ns |
Urea (mg/dl) | 30.80 ± 14.00 | 39.33 ± 7.84 | ns |
Creatinine (mg/dl) | 0.92 ± 0.27 | 1.00 ± 0.32 | ns |
Uric acid (mg/dl) | 5.28 ± 0.48 | 6.53 ± 0.46 | 0.001 |
CRP (mg/l) | 1.4 ± 1.1 | 2.7 ± 2.5 | ns |
GRF MDRD (ml/min) | 792 ± 22 | 71 ± 19 | ns |
Biomarkers | |||
NT-proBNP (pg/ml) | 1098.00 ± 1483.86 | 1151.24 ± 1371.00 | ns |
TNF-alpha (pg/ml) | 19.10 ± 6.40 | 27.53 ± 7.39 | 0.001 |
Interleukin 6 (pg/ml) | 14.90 ± 4.70 | 19.00 ± 3.94 | 0.01 |
Syndecan 4 (ng/ml) | 4.40 ± 3.10 | 5.21 ± 4.00 | ns |
Cystatin C (mg/l) | 1.17 ± 0.39 | 1.00 ± 0.18 | ns |
TGF-beta (pg/ml) | 470.19 ± 166.50 | 463.00 ± 156.78 | ns |
Echocardiographic parameters | |||
LVdD (cm) | 6.6 ± 0.8 | 6.4 ± 1.8 | ns |
LVsD (cm) | 5.1 ± 0.9 | 5.1 ± 1 | ns |
LVEF (%) | 38.4 ± 8.8 | 33.9 ± 11.5 | ns |
LA diameter (cm) | 4.7 ± 0.8 | 8.0 ± 10.5 | ns |
RVdD(cm) | 2.9 ± 0.4 | 3.0 ± 0.6 | ns |
LVEdV (ml) | 187.0 ± 37.0 | 191.6 ± 72.9 | ns |
LVsV(ml) | 118.9 ± 41.0 | 104.0 ± 41.5 | ns |
TEI index | 0.7 ± 0.2 | 0.5 ± 0.4 | ns |
Mitral regurgitation dP/dT (mmHg/s) | 569.5 ± 294.1 | 392.5 ± 83.0 | ns |
Clinical state of patients | |||
6-MWT (m) | 419.3 ± 116.0 | 376.7 ± 114.3 | ns |
NYHA class (No. of patients [%]) | |||
I | 1 (5) | 3 (13) | ns |
II | 12 (54) | 10 (44) | |
III | 8 (36) | 7 (30) | |
IV | 1 (5) | 3 (13) | |