Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells

Table 1 Biochemical data on the two groups of mice (mean ± SD)

Indexes	Control group (n = 8)	HF group (n = 8)
Body weight (g)	28.4 ± 2.0	28.2 ± 1.82
Kidney weight/body weight (mg/g)	14.0 ± 1.8	14.2 ± 1.5
TG (mmol/l)	3.1 ± 0.6	7.5 ± 2.0*
TC (mmol/l)	13.7 ± 2.7	27.8 ± 4.0*
HDL (mmol/l)	1.0 ± 0.4	0.8 ± 0.34
LDL (mmol/l)	5.8 ± 1.5	11.6 ± 3.0*

Compared to the controls, the mice fed with a high fat diet developed hyperlipidemia. TG: triglycerides, TC: total cholesterol, HDL: high-density lipoprotein, LDL: low-density lipoprotein. * P < 0.05 vs. control.

ISSN: 1476-511X