Cardiometabolic risk factors among HIV patients on antiretroviral therapy

Table 3 Comparison of metabolic changes by period and combination antiretroviral therapy regimen in the DGPLEAD study

	AZT+3TC+NVP (n = 58)			D4T+3TC+NVP (n = 43)			Other (n = 17)			Global P**
Variable	Baseline	End	P*	Baseline	End	P*	Baseline	End	P*
HDL-c, mmol/L	0.80 [0.61, 1.15]	1.42 [1.17, 1.73]	< 0.001	0.65 [0.34, 0.92]	1.27 [1.02, 1.70]	< 0.001	0.76 [0.57, 1.03]	1.22 [0.96, 1.47]	0.003	0.22
LDL-c, mmol/L	2.24 [1.76, 2.52]	2.25 [2.00, 2.75]	0.51	2.01 [1.44, 2.42]	2.27 [1.81, 2.61]	0.007	2.06 [1.71, 2.58]	2.14 [1.84, 2.18]	0.41	0.13
TC, mmol/L	3.59 [3.23, 3.99]	4.00 [3.50, 4.68]	< 0.001	3.46 [2.85, 4.08]	4.13 [3.59, 4.58]	< 0.001	3.40 [2.86, 3.87]	3.50 [3.40, 3.73]	0.77	0.04
TC:HDL-c ratio	4.54 [3.44, 5.84]	2.78 [2.34, 3.49]	< 0.001	5.32 [3.97, 8.93]	3.08 [2.85, 3.94]	< 0.001	4.34 [3.33, 5.82]	2.73 [2.31, 3.00]	0.001	0.36
TG, mmol/L	1.01 [0.86, 1.33]	1.06 [0.70, 1.41]	0.93	1.16 [1.88, 1.60]	1.05 [0.85, 1.44]	0.41	0.95 [0.77, 1.05]	0.91 [0.68, 1.14]	0.17	0.33
Insulin, μU/mL	3.00 [2.00, 5.00]	6.70 [4.00, 12.50]	< 0.001	3.00 [1.50, 5.00]	7.65 [3.00, 13.45]	< 0.001	2.60 [1.20, 5.90]	4.65 [3.15, 9.70]	0.07	0.18
Glucose, mmol/L	3.90 [3.60, 4.30]	4.20 [3.60, 4.60]	0.37	3.70 [3.40, 4.10]	3.80 [3.20, 4.60]	0.23	3.60 [3.00, 3.90]	3.70 [3.50, 4.20]	0.17	0.79
HOMA-IR	0.53 [0.33, 0.93]	1.12 [0.62, 2.41]	< 0.001	0.50 [0.28, 1.00]	1.39 [0.49, 2.49]	< 0.001	0.45 [0.16, 0.98]	0.72 [0.49, 1.53]	0.08	0.07
BMI, kg/m²	20.1 [18.2, 21.5]	20.3 [19.1, 22.2]	0.001	19.6 [18.4, 21.1]	20.6 [19.2, 22.4]	< 0.001	19.4 [17.6, 22.4]	20.1 [18.6, 22.3]	0.49	0.26
Weight, kg	55.3 [51.0, 62.0]	58.0 [53.5, 64.0]	0.001	52.0 [46.0, 55.0]	56.0 [47.0, 59.0]	< 0.001	53.0 [49.0, 60.5]	55.0 [50.0, 57.0]	0.49	0.30

Values are reported as median [25^th percentile, 75^th percentile].
* P-values obtained through Wilcoxon signed rank tests.
** P-values are from ANOVA with robust variance estimators comparing changes from baseline to 90 days after initiating cART and are adjusted for sex.
DGPLEAD, Diet, Genetic Polymorphisms in Lipid-Metabolizing Enzyme genes, and Antiretroviral Therapy-Related Dyslipidemia.

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