Figure 1From: Roles of lipid metabolism in keloid developmentOverview of the pro- and anti-inflammatory lipid modulators that are generated by lipid metabolism. Lipid metabolism produces not only the classical pro-inflammatory lipid modulators, namely, the prostaglandins, leukotrienes, and thromboxanes, it also generates anti-inflammatory lipid modulators, namely, lipoxins, protectins, and resolvins (in dashed boxes). The possibility that keloid formation may be promoted by imbalances between the pro- and anti-inflammatory lipid modulators is attracting increasing interest in keloid research. (AA: arachidonic acid; ALA:α-linolenic acid; COX: cycloxygenase; DGLA: dihomo-γ-linolenic acid; DHA: docosahexaenoic acid; ETA: eicosatrienoic acid; EPA: eicosapentaenoic acid; GLA: γ-linolenic acid; HETrE: hydroxyeicosatrienoic acid; HPEPE: hydroperoxyeicosapentaenoic acid; HPETE; hydroperoxyeicosatetraenoic acid; HEPE: hydroxyeicosapentaenoic acid; HETE: hydroxyeicosatetraenoic acid;LA: linoleic acid;LT: leukotriene; LOX: lipoxygenase; LX: lipoxin; NPD1: neuroprotectin D1; PG: prostaglandin;PLA2: phospholipase A2; SA: stearidonic acid; TX: thromboxane; Rv: resolvin).Back to article page