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Table 1 Fold changes in significantly changed lipids in brain tissues

From: Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

Molecular species

4 months

10 months

15 months

 

Fold Change1

p-value2

Fold Change1

p-value2

Fold Change1

p-value2

Phosphatidylcholine (PC)

      

 30:0PC (14:0/16:0)

1.35

0.026*

1.14

0.200

1.03

0.198

 32:0PC (16:0/16:0)

1.02

0.815

0.87

0.093

0.83

0.011*

 34:2PC (16:0/18:2)

1.32

0.190

1.63

0.014*

1.03

0.282

 36:3PC (16:0/20:3)

1.06

0.550

1.07

0.441

1.28

0.029*

 38:1PC (18:0/20:1)

0.84

0.092

0.87

0.155

0.77

0.010**

 38:4PC (16:0/22:4)

1.07

0.462

0.92

0.279

0.86

0.011*

 38:5PC (18:1/20:4)

1.10

0.104

0.93

0.426

0.88

0.021*

 40:4PC (18:0/22:4)

1.05

0.596

0.91

0.188

0.84

0.003**

 40:7PC (18:1/22:6)

1.00

0.984

0.90

0.615

0.87

0.021*

 34:1ePC

1.04

0.542

0.92

0.338

0.86

0.029*

Phosphatidylethanolamine (PE)

      

 38:1PE (20:0/18:1)

0.74

0.021*

0.89

0.413

0.66

0.024*

 38:5PE (18:1/20:4)

0.99

0.942

0.94

0.352

0.85

0.023*

 40:4PE (18:0/22:4)

1.10

0.265

0.91

0.269

0.89

0.035*

Ethanolamine plasmalogen (pPE)

      

 36:2pPE (p18:1/18:1)

0.76

0.299

0.88

0.183

0.86

0.042*

 36:4pPE (p16:0/20:4)

1.02

0.810

0.91

0.359

0.89

0.027*

 38:2pPE (p18:1/20:1)

0.78

0.037*

0.83

0.037*

0.76

0.034*

 38:4pPE (p16:0/22:4)

1.02

0.682

0.92

0.310

0.82

0.009**

 38:4pPE (p18:0/20:4)

0.94

0.819

0.93

0.796

0.87

0.029*

 40:4pPE (p18:0/22:4)

0.96

0.611

0.94

0.399

0.88

0.013*

 40:6pPE (p18:0/22:6)

1.02

0.822

0.89

0.182

0.87

0.043*

Sphingomyelin (SM)

      

 34:1SM (d18:1/N16:0)

0.98

0.863

0.97

0.675

0.76

0.007**

 36:2SM (d18:2/N18:0)

0.94

0.335

0.81

0.010*

0.86

0.027*

 38:1SM (d18:1/N20:0)

0.90

0.278

0.85

0.067

0.79

0.006**

 42:2SM (d18:1/N24:1)

0.78

0.048*

0.86

0.388

0.60

0.066

Cerebroside

      

 42:2cerebroside

0.81

0.045*

0.92

0.334

0.84

0.137

Diacylglycerol (DAG)

      

 38:4DAG

0.94

0.420

0.74

0.016*

0.78

0.043*

Triacylglycerol (TAG)

      

 52:3TAG (16:0/18:1/18:2, 16:1/18:1/18:1)

0.87

0.353

0.68

0.143

0.40

0.002**

 53:6TAG

1.05

0.765

0.91

0.648

0.54

0.003**

 54:4TAG (16:0/18:0/20:4)

1.09

0.463

1.04

0.801

0.31

<0.001***

 60:12TAG (16:0/22:6/22:6)

0.99

0.935

1.33

0.011*

0.87

0.544

Cholesterol ester (ChE)

      

 22:6ChE

5.22

0.002**

6.96

0.004**

5.43

0.032*

  1. 1 Fold change (ratio of APP/tau to wild-type) is the mean of N=3-5.
  2. 2 Welch’s t-test (*p<0.05, **p<0.01,***p<0.001).