Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

Table 2 Fold changes of the significantly changed oxidized fatty acids in brain tissues

Molecular species	4 months		10 months		15 months
Molecular species	Fold Changes¹	p-value²	Fold Changes¹	p-value²	Fold Changes¹	p-value²
*Metabolites derived from arachidonic acid*
Prostaglandin D₂	0.99	0.941	0.46	< 0.001***	0.63	0.059
Thromboxane B₂	1.24	0.113	0.66	0.013*	1.07	0.845
12-HHT	1.19	0.149	0.67	0.005**	0.98	0.952
12-HETE	0.90	0.777	1.77	0.049*	1.03	0.931
15-HETE	1.03	0.747	0.71	<0.001***	0.87	0.604
11,12-EpETrE	0.84	0.225	0.83	0.007**	1.04	0.886
14,15-EpETrE	0.85	0.053	0.79	0.029*	0.97	0.810
*Metabolites derived from eicosapentaenoic acid*
17,18-diHETE	2.12	< 0.001***	1.10	0.602	1.42	0.300
*Metabolites derived from docosahexaenoic acid*
19,20-diHDoPE	1.72	0.002**	1.20	0.251	1.38	0.261

¹ Fold changes (ratio of APP/tau to wild-type) are means of N=3-5.
² Welch’s t-test (*p<0.05, **p<0.01,***p<0.001).
HHT, hydroxy-heptadecatrienoic acid; HETE, hydroxyeicosatetraenoic acid; EpETrE, epoxyeicosatrienoic acid; diHETE, dihydroxyeicosatetraenoic acid; diHDoPE, dihydroxydocosapentaenoic acid.

ISSN: 1476-511X