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Table 3 Fold changes of the significantly changed lipids in plasma

From: Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

Molecular species

4 months

10 months

15 months

Fold Changes1

p-value2

Fold Changes1

p-value2

Fold Changes1

p-value2

Phosphatidylcholine (PC)

 16:1LPC

0.99

0.960

0.59

0.026*

1.07

0.724

 18:0LPC

1.50

0.019*

1.27

0.281

1.01

0.921

 20:5LPC 3

1.45

0.011*

0.82

0.440

1.26

0.190

 22:6LPC

1.45

0.011*

1.03

0.889

1.10

0.619

 34:1PC (16:0/18:1)

1.24

0.037*

1.00

0.983

1.27

0.071

 34:2PC (16:0/18:2)

1.27

0.053

1.17

0.007**

1.21

0.015*

 34:3PC (16:0/18:3)

1.06

0.698

0.65

0.034*

0.98

0.936

 35:2PC

1.68

0.030*

1.55

0.013*

1.27

0.035*

 36:1PC (18:0/18:1)

1.55

0.010**

1.16

0.256

1.19

0.109

 36:2PC (18:0/18:2)

1.48

0.024*

1.35

0.017*

1.11

0.139

 36:5PC (16:0/20:5)

1.51

0.011*

0.81

0.509

1.40

0.374

 37:2PC (19:0/18:2)

1.33

0.144

1.47

0.008**

1.26

0.071

 38:3PC (18:0/20:3)

1.52

0.045*

1.38

0.209

1.17

0.497

 38:4PC (18:1/20:3)

0.99

0.957

0.63

0.031*

0.82

0.137

 38:5PC (18:0/20:5)

1.74

0.008**

1.08

0.783

1.24

0.266

 38:5PC (18:1/20:4)

1.13

0.331

0.79

0.018*

0.84

0.149

 38:7PC

1.08

0.644

0.48

0.019*

0.94

0.807

 40:4PC (20:0/20:4)

1.50

0.018*

1.47

0.077

1.12

0.313

 40:5PC (18:0/22:5)

1.71

0.007**

1.25

0.182

1.30

0.349

 40:6PC (18:0/22:6)

1.64

0.033*

1.39

0.099

1.06

0.629

 40:7PC (18:1/22:6)

1.06

0.642

0.72

0.022*

0.73

0.072

 42:6PC (20:0/22:6)

1.41

0.002**

1.52

0.012*

1.38

0.110

 34:2ePC (16:0e/18:2)

1.52

<0.001***

1.81

<0.001***

1.47

0.011*

phosphatidylinositol (PI)

 38:5PI (18:0/20:5)

1.53

0.024*

0.92

0.748

2.00

0.002**

Sphingomyelin (SM)

 34:1SM (d18:1/N16:0)

1.25

0.057

1.35

0.027*

1.30

0.032*

 42:2SM

1.37

0.051

1.39

0.024*

1.38

0.069

 42:3SM (d18:2/N24:1)

1.48

0.030*

1.22

0.061

1.30

0.141

Triacylglycerol (TAG)

 52:3TAG (16:0/18:1/18:2)

1.21

0.557

1.21

0.558

0.58

0.045*

 52:4TAG (16:0/18:2/18:2)

1.57

0.250

1.41

0.421

0.40

0.032*

 52:5TAG (16:0/18:2/18:3)

1.04

0.903

0.74

0.314

0.49

0.011*

 54:3TAG (18:0/18:1/18:2)

0.64

0.553

0.62

0.411

0.48

0.043*

 54:4TAG (18:1/18:1/18:2)

0.93

0.919

0.97

0.950

0.37

0.038*

 56:6TAG (18:0/18:2/20:4)

2.00

0.209

2.75

0.016*

0.82

0.500

 58:10TAG (16:0/20:4/22:6)

1.40

0.311

2.07

0.020*

0.88

0.509

 58:11TAG

2.44

0.038*

1.92

0.027*

1.70

0.205

 58:11TAG

1.87

0.030*

1.69

0.176

1.64

0.383

 58:12TAG (18:3/20:4/20:5)

2.06

0.032*

1.91

0.168

2.65

0.005**

 60:10TAG

1.68

0.131

2.24

0.021*

0.90

0.762

 60:11TAG (16:2/22:4/22:5)

1.43

0.178

2.04

<0.001***

1.51

0.168

 60:11TAG (16:0/22:5/22:6)

1.66

0.335

1.98

0.007**

1.39

0.401

 60:11TAG (18:2/20:3/22:6)

1.80

0.018*

2.13

0.005**

1.42

0.304

 60:12TAG (18:2/20:5/22:5)

1.67

0.106

1.75

0.177

2.80

0.011*

 60:12TAG (18:3/20:4/22:5)

1.38

0.375

2.85

0.007**

1.37

0.356

 60:12TAG (18:3/20:4/22:5)

2.25

0.039*

2.08

0.068

2.81

0.087

 60:12TAG (18:3/20:4/22:5)

2.29

0.154

2.04

0.021*

1.64

0.308

 60:13TAG (18:2/20:5/22:6)

1.66

0.086

2.00

0.015*

2.58

0.067

 62:11TAG (18:2/22:4/22:5, 16:1/22:5/24:5)

1.64

0.063

1.77

0.031*

1.58

0.232

 62:12TAG (18:3/22:4/22:5)

1.56

0.147

2.27

0.003**

1.35

0.370

 62:13TAG (16:1/22:6/24:6, 20:2/20:5/22:6)

2.28

0.121

1.77

0.003**

1.82

0.363

 62:13TAG (18:1/22:6/22:6)

2.09

0.106

2.36

0.029*

2.53

0.272

 62:14TAG (18:2/22:6/22:6)

2.25

0.119

2.45

<0.001***

2.20

0.274

 64:14TAG

1.57

0.215

2.06

0.008**

1.95

0.251

 65:14TAG

1.83

0.052

2.03

<0.001***

1.52

0.299

Cholesterol ester (ChE)

 18:1ChE

0.74

0.016*

0.78

0.089

1.12

0.423

 18:2ChE

1.16

0.170

1.17

0.029*

1.16

0.307

 20:5ChE

1.38

0.041*

0.93

0.762

1.33

0.138

  1. 1 Fold changes (ratio of APP/tau to wild-type) are means of N=3-5.
  2. 2 Welch’s t-test (*p<0.05, **p<0.01,***p<0.001).
  3. 3 This specie was picked up not from OPLS-DA loading S-plot but manually.