Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

Table 4 Fold changes of the significantly changed oxidized fatty acids in plasma

Molecular species	4 months		10 months		15 months
	Fold Changes¹	p-value²	Fold Changes¹	p-value²	Fold Changes¹	p-value²
*Metabolites derived from arachidonic acid*
17-HETE	1.59	0.018*	1.41	0.112	1.36	0.111
18-HETE	1.46	0.021*	1.48	0.105	1.67	0.011*
5,15-diHETE	2.02	0.002**	1.42	0.159	1.97	0.002**
*Metabolites derived from eicosapentaenoic acid*
8-HEPE	1.55	0.125	1.65	0.095	2.00	0.006**
15-HEPE	1.20	0.314	1.47	0.197	1.51	0.020*
17,18-EpETE	1.66	0.165	1.46	0.157	1.85	0.004**
14,15-diHETE	2.16	0.032*	1.80	0.051	2.21	0.122
17,18-diHETE	2.11	0.003**	1.51	0.116	2.22	0.004**
*Metabolites derived from docosahexaenoic acid*
7-HDoHE	1.28	0.336	1.46	0.102	1.46	0.044*
10-HDoHE	1.62	0.047*	1.11	0.550	1.52	0.252
19,20-diHDoPE	1.67	0.010*	1.42	0.027*	1.80	0.033*
*Metabolites derived from linolenic acid*
9-HOTrE(alpha)	1.64	0.202	2.53	0.023*	2.08	0.108
13-HOTrE(alpha)	1.50	0.147	1.87	0.041*	1.73	0.008**

¹ Fold changes (ratio of APP/tau to wild-type) are means of N=3-5.
² Welch’s t-test (*p<0.05, **p<0.01,***p<0.001).
HETE, hydroxyeicosatetraenoic acid; diHETE, dihydroxyeicosatetraenoic acid; HEPE, hydroxyeicosapentaenoic acid; EpETE, epoxyeicosatetraenoic acid; HDoHE, hydroxydocosahexaenoic acid; diHDoPE, dihydroxydocosapentaenoic acid; HOTrE, hydroxyoctadecatrienoic acid .

ISSN: 1476-511X