Table 2 Correlations between PUFA content in adipose tissue and 5-lipoxygenase pathway constituents in plaque and urine
Adipose tissue arachidonic acid (% of total fatty acids) | Adipose tissue eicosapentaenoic acid (% of total fatty acids) | |||||
|---|---|---|---|---|---|---|
r | 95% CI | p | r | 95% CI | p | |
Plaque | ||||||
5-lipoxygenase expression (% of plaque area) | 0.32 | 0.03 to 0.56 | 0.03 | 0.14 | −0.16 to 0.41 | 0.37 |
Leukotriene B4 (ng/g) | 0.22 | −0.08 to 0.42 | 0.14 | 0.25 | −0.05 to 0.50 | 0.10 |
Cysteinyl leukotrienes (ng/g) | −0.11 | −0.39 to 0.19 | 0.46 | 0.02 | −0.27 to 0.31 | 0.87 |
Urine | ||||||
Leukotriene E4 (pg/mg creatinine) | 0.02 | −0.28 to 0.31 | 0.92 | −0.12 | −0.40 to 0.18 | 0.44 |