Table 4 Comparison of serum lipid and PCSK9 concentrations in non-carriers versus carriers of a given PCSK9 variant values
PCSK9 Genotype | Total Cholesterol (mmol/L) | p-value | Triglyceride (mmol/L) | p-value | HDL Cholesterol (mmol/L) | p-value | LDL Cholesterol (mmol/L) | p-value | Serum PCSK9 (ng/mL) | p-value |
|---|---|---|---|---|---|---|---|---|---|---|
Non-Carrier (n = 155) | 5.67 ± 1.16 | 1.54 ± 0.73 | 1.19 ± 0.35 | 3.78 ± 1.00 | 327.2 ± 130.6 | |||||
L10A53V | 0.0047 | 0.56 | 0.63 | 0.0002 | 0.76 | |||||
Carrier (n = 52) | 5.13 ± 0.99 | 1.66 ± 0.82 | 1.21 ± 0.49 | 3.17 ± 0.92 | 326.5 ± 133.0 | |||||
Non-Carrier (n = 150) | 5.59 ± 1.19 | 1.54 ± 0.75 | 1.19 ± 0.37 | 3.70 ± 1.06 | 338.6 ± 136.2 | |||||
I474V | 0.13 | 0.57 | 0.86 | 0.056 | 0.033 | |||||
Carrier (n = 57) | 5.35 ± 0.98 | 1.61 ± 0.76 | 1.21 ± 0.44 | 3.42 ± 0.86 | 296.7 ± 111.0 | |||||
Non-Carrier (n = 192) | 5.56 ± 1.14 | 1.59 ± 0.77 | 1.20 ± 0.40 | 3.64 ± 1.01 | 328.1 ± 127.0 | |||||
E670G | 0.19 | 0.13 | 0.36 | 0.59 | 0.44 | |||||
Non-Carrier (n = 15) | 5.11 ± 1.12 | 1.27 ± 0.48 | 1.10 ± 0.30 | 3.45 ± 1.11 | 313.8 ± 177.9 |