Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

Table 5 Comparison of serum lipid and PCSK9 concentrations in non-carriers of any PCSK9 variant versus carriers of only a given PCSK9 variant values

PCSK9 Genotype	Total Cholesterol (mmol/L)	p-value	Triglyceride (mmol/L)	p-value	HDL Cholesterol (mmol/L)	p-value	LDL Cholesterol (mmol/L)	p-value	Serum PCSK9 (ng/mL)	p-value
No Variant (n = 101)	5.82 ± 1.15		1.55 ± 0.72		1.19 ± 0.34		3.93 ± 0.97		341.0 ± 128.9
L10A53V		*0.0032*		0.82		0.64		*0.0005*		0.84
Only (n = 29)	5.09 ± 0.96		1.67 ± 0.86		1.18 ± 0.41		3.15 ± 0.96		352.7 ± 138.5
No Variant (n = 101)	5.82 ± 1.15		1.55 ± 0.72		1.19 ± 0.34		3.93 ± 0.97		341.0 ± 128.9
I474V		0.097		0.53		0.86		*0.050*		0.087
Only (n = 37)	5.48 ± 1.01		1.67 ± 0.81		1.18 ± 0.39		3.54 ± 0.90		301.3 ± 110.2
No Variant (n = 101)	5.82 ± 1.15		1.55 ± 0.72		1.19 ± 0.34		3.93 ± 0.97		341.0 ± 128.9
E670G		*0.043*		*0.039*		0.69		0.14		0.34
Only (n = 9)	4.88 ± 1.01		1.12 ± 0.41		1.14 ± 0.37		3.24 ± 1.08		329.3 ± 227.8

Variant values represent mean ± SD. Differences between groups were determined by Mann Whitney test with level of significance as p < 0.05.

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