Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern

Table 4 Haplotype analysis of SNPs of PTPN11 on the lipid levels

Haplotype	Frequency	TG		TC		HDL-C		LDL-C
Haplotype	Frequency	b	P	b	P	b	P	b	P
GTATA	41.17%	Reference	–	Reference	–	Reference	–	Reference	–
GCGTG	27.75%	0.054	0.042	0.013	0.157	−0.018	0.099	0.006	0.624
GTGTA	15.26%	0.028	0.389	−0.006	0.619	−0.002	0.841	−0.017	0.265
ATGCG	12.71%	0.050	0.165	0.027	0.030	0.014	0.343	0.028	0.082

Differences between haplotype groups were assessed using the linear regression model adjusted for age, sex, BMI and waist circumference. P value in bold indicated the difference was significant comparing to the most common haplotype group (P<0.05).
SNPs were aligned as rs2301756, rs12423190, rs12229892, rs7958372 and rs4767860.

ISSN: 1476-511X