Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro

Table 2 Kinetic parameters of LDL + HDL ₂ oxidation in healthy subjects according to FADS2 genotype

Genotype	TT and T –	– –	P	P*
N	48	10
LDL + HDL ₂
Lag time (min)	56.1 ± 6.2	57 ± 5.4	0.764	0.296
Rate (μmol/l/min)^a	0.685 ± 0.075	0.656 ± 0.085	0.027	0.027
Max (nmol/mg)^b	777 ± 50	735 ± 74	0.033	0.034

Values are mean ± SD. ^a Rate means maximal formation rate of conjugated dienes during oxidation. Calculation of the diene concentration is based on ϵ_{234 nm} = 29500 l/mol/cm of the conjugated dienes. ^b Max is the maximal amount of dienes produced per mg of LDL protein.
*; adjusted for age and gender.

ISSN: 1476-511X