Levels of EPA and AA-derived metabolites in colon. Free fatty acid levels of EPA-derived metabolites prostaglandin E3 (PGE3); thromboxane B3 (TxB3); leukotriene B5 (LTB5); 5-hydroxyeicosapentaenoic acid (5-HEPE); 17,18-epoxyeicosatetraenoic acid (17,18-EEP); and the AA-derived metabolites prostaglandin J2 (PGJ2); 8,9-epoxyeicosatrienoic acid (8,9-EET); prostaglandin E2 (PGE2) (from A-H respectively) are shown. Black bars are median values and each dot represents the value obtained with an individual mouse where dark circles are tRag2 and open circles are tRag2 + FO. Statistics are shown as * when P <0.05, ** when P <0.01 and *** when P <0.001. Of note whole set of metabolites measured and corresponding values are given in Additional files 1 and 2.