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Table 5 In vivo modulation effect of ME and VO fractions on hepatic HMG-CoA reductase activity in atherogenic suspension fed rats

From: Elucidation of mechanisms of actions of thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters in experimental hyperlipidemia

Group HMG-CoA reductase activity†
NLP-C 28.90 ± 0.04
HLP-C 19.72 ± 0.07 (± 31.76%)α
HLP- ME 16.33 ± 0.06 (-43.49%)a
HLP-VO 16.74 ± 0.05 (-42.07%)a
  1. † Its activity is expressed as percent of nmoles of HMG-CoA to mevalonate formed per mg liver protein. Each value represents mean ± SD from pooled liver samples in each group. The values were highly significant from NLP-C at ap < 0.001, and the values between the treated groups were also statistically significant (p < 0.05).