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Figure 2 | Lipids in Health and Disease

Figure 2

From: Role of ceramide in diabetes mellitus: evidence and mechanisms

Figure 2

Regulation of sphingolipid biosynthesis. Details of these processes and abbreviations are described in the text. Briefly, ceramide is formed from L-serine and palmitoyl CoA via de novo pathway. Ceramide can also be formed from SM hydrolysis by SMase, glucosyl ceramide hydrolysis by Glucocerebrosidase and from sphingosine by ceramide synthase. Sphingolipid metabolites are depicted in box and enzymes are shown outside the box. Some pharmacological inhibitors of sphingolipid biosynthetic enzymes are also shown.

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