Table 3 Impact of MTHFR C677T on serum lipid levels (mmol/L)
From: Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation
Group | Genotype | n | TC | TG | HDL-C | LDL-C |
|---|---|---|---|---|---|---|
All | ||||||
CC | 700 | 5.04 ± 0.97 | 0.94 (0.52) | 1.66 ± 0.39 | 2.86 ± 0.90 | |
CT | 266 | 5.15 ± 1.01 | 0.98 (0.53) | 1.63 ± 0.39 | 3.01 ± 0.84 | |
TT | 43 | 4.86 ± 1.31 | 0.88 (0.41) | 1.61 ± 0.46 | 2.70 ± 0.98 | |
F | — | 1.099 | 0.617 | 0.190 | 1.537 | |
p | — | 0.334 | 0.540 | 0.827 | 0.215 | |
CC | 700 | 5.04 ± 0.97 | 0.94 (0.52) | 1.66 ± 0.39 | 2.86 ± 0.90 | |
CT/TT | 309 | 5.11 ± 1.06 | 0.96 (0.50) | 1.64 ± 0.41 | 2.97 ± 0.87 | |
F | — | 0.163 | 1.335 | 0.022 | 0.001 | |
p | — | 0.686 | 0.248 | 0.883 | 0.974 | |
Male | ||||||
CC | 178 | 5.00 ± 1.04 | 0.95 (0.70) | 1.61 ± 0.41 | 2.84 ± 0.96 | |
CT | 73 | 4.78 ± 0.97 | 0.87 (0.48) | 1.59 ± 0.42 | 2.72 ± 0.83 | |
TT | 18 | 4.70 ± 0.98 | 0.83 (0.45) | 1.68 ± 0.57 | 2.58 ± 0.73 | |
F | — | 1.560 | 2.001 | 0.477 | 1.106 | |
p | — | 0.212 | 0.137 | 0.621 | 0.332 | |
CC | 178 | 5.00 ± 1.04 | 0.95 (0.70) | 1.61 ± 0.41 | 2.84 ± 0.96 | |
CT/TT | 91 | 4.77 ± 0.97 | 0.86 (0.46) | 1.61 ± 0.45 | 2.69 ± 0.81 | |
F | — | 3.042 | 3.837 | 0.025 | 1.830 | |
p | — | 0.082 | 0.051 | 0.876 | 0.177 | |
Female | ||||||
CC | 522 | 5.05 ± 0.95 | 0.93 (0.49) | 1.68 ± 0.38 | 2.87 ± 0.88 | |
CT | 193 | 5.29 ± 0.99 | 1.02 (0.62) | 1.65 ± 0.38 | 3.12 ± 0.82 | |
TT | 25 | 4.97 ± 1.52 | 1.01 (0.43) | 1.61 ± 0.46 | 2.79 ± 1.13 | |
F | — | 3.762 | 0.452 | 0.181 | 4.227 | |
p | — | 0.024 | 0.637 | 0.835 | 0.015 | |
CC | 522 | 5.05 ± 0.95 | 0.93 (0.49) | 1.68 ± 0.38 | 2.87 ± 0.88 | |
CT/TT | 218 | 5.26 ± 1.06 | 1.02 (0.53) | 1.65 ± 0.39 | 3.08 ± 0.86 | |
F | — | 4.183 | 0.766 | 0.232 | 4.504 | |
p | — | 0.041 | 0.382 | 0.630 | 0.034 | |
LG | ||||||
CC | 332 | 5.12 ± 1.00 | 0.97 (0.49) | 1.59 ± 0.37 | 3.04 ± 0.87 | |
CT | 159 | 5.22 ± 1.06 | 0.99 (0.50) | 1.61 ± 0.38 | 3.09 ± 0.86 | |
TT | 25 | 5.13 ± 1.31 | 1.07 (0.44) | 1.56 ± 0.51 | 3.01 ± 0.96 | |
F | — | 0.148 | 0.017 | 0.073 | 0.305 | |
p | — | 0.863 | 0.983 | 0.930 | 0.737 | |
CC | 332 | 5.12 ± 1.00 | 0.97 (0.49) | 1.59 ± 0.37 | 3.04 ± 0.87 | |
CT/TT | 184 | 5.20 ± 1.09 | 1.00 (0.48) | 1.61 ± 0.40 | 3.08 ± 0.88 | |
F | — | 0.276 | 0.003 | 0.000 | 0.558 | |
p | — | 0.600 | 0.959 | 0.993 | 0.456 | |
Male | ||||||
CC | 83 | 5.00 ± 1.11 | 0.94 (0.39) | 1.57 ± 0.41 | 2.96 ± 0.95 | |
CT | 35 | 4.67 ± 1.11 | 0.87 (0.29) | 1.54 ± 0.39 | 2.67 ± 0.97 | |
TT | 9 | 4.71 ± 1.09 | 0.84 (0.53) | 1.55 ± 0.64 | 2.76 ± 0.77 | |
F | — | 1.377 | 0.983 | 0.081 | 1.255 | |
p | — | 0.256 | 0.377 | 0.922 | 0.289 | |
CC | 83 | 5.00 ± 1.11 | 0.94 (0.39) | 1.57 ± 0.41 | 2.96 ± 0.95 | |
CT/TT | 44 | 4.67 ± 1.09 | 0.87(0.34) | 1.54 ± 0.44 | 2.69 ± 0.92 | |
F | — | 2.749 | 1.398 | 0.158 | 2.450 | |
p | — | 0.100 | 0.239 | 0.691 | 0.120 | |
Female | ||||||
CC | 249 | 5.15 ± 0.96 | 0.98 (0.52) | 1.60 ± 0.35 | 3.06 ± 0.84 | |
CT | 124 | 5.37 ± 1.00 | 1.04 (0.62) | 1.63 ± 0.38 | 3.21 ± 0.80 | |
TT | 16 | 5.37 ± 1.40 | 1.09 (0.47) | 1.56 ± 0.44 | 3.15 ± 1.05 | |
F | — | 2.179 | 2.148 | 0.605 | 1.188 | |
p | — | 0.115 | 0.113 | 0.546 | 0.306 | |
CC | 249 | 5.15 ± 0.96 | 0.98 (0.52) | 1.60 ± 0.35 | 3.06 ± 0.84 | |
CT/TT | 140 | 5.37 ± 1.04 | 1.07 (0.61) | 1.63 ± 0.38 | 3.20 ± 0.83 | |
F | — | 4.366 | 3.091 | 0.580 | 2.307 | |
p | — | 0.037 | 0.080 | 0.447 | 0.130 | |
Non-LG | ||||||
CC | 368 | 4.97 ± 0.95 | 0.91 (0.60) | 1.73 ± 0.40 | 2.70 ± 0.90 | |
CT | 107 | 5.06 ± 0.92 | 0.95 (0.59) | 1.66 ± 0.41 | 2.90 ± 0.79 | |
TT | 18 | 4.47 ± 1.25 | 0.85 (0.24) | 1.75 ± 0.49 | 2.28 ± 0.86 | |
F | — | 4.138 | 2.135 | 0.728 | 4.601 | |
p | — | 0.017 | 0.119 | 0.483 | 0.010 | |
CC | 368 | 4.97 ± 0.95 | 0.91 (0.60) | 1.73 ± 0.40 | 2.70 ± 0.90 | |
CT/TT | 125 | 4.98 ± 1.00 | 0.89 (0.47) | 1.68 ± 0.42 | 2.81 ± 0.83 | |
F | — | 0.137 | 1.833 | 0.032 | 0.128 | |
p | — | 0.712 | 0.176 | 0.858 | 0.721 | |
Male | ||||||
CC | 95 | 4.99 ± 0.99 | 0.97 (0.91) | 1.63 ± 0.41 | 2.75 ± 0.96 | |
CT | 38 | 4.89 ± 0.83 | 0.89 (0.70) | 1.64 ± 0.45 | 2.76 ± 0.68 | |
TT | 9 | 4.69 ± 0.92 | 0.81 (0.49) | 1.81 ± 0.49 | 2.40 ± 0.68 | |
F | — | 0.677 | 1.372 | 1.096 | 0.963 | |
p | — | 0.510 | 0.257 | 0.337 | 0.384 | |
CC | 95 | 4.99 ± 0.99 | 0.97 (0.91) | 1.63 ± 0.41 | 2.75 ± 0.96 | |
CT/TT | 47 | 4.86 ± 0.84 | 0.85 (0.67) | 1.67 ± 0.46 | 2.69 ± 0.69 | |
F | — | 0.670 | 2.637 | 0.537 | 0.212 | |
p | — | 0.415 | 0.107 | 0.465 | 0.646 | |
Female | ||||||
CC | 273 | 4.96 ± 0.94 | 0.90 (0.52) | 1.76 ± 0.40 | 2.69 ± 0.88 | |
CT | 69 | 5.15 ± 0.96 | 1.00 (0.49) | 1.68 ± 0.38 | 2.97 ± 0.84 | |
TT | 9 | 4.26 ± 1.54 | 0.85 (0.24) | 1.70 ± 0.52 | 2.16 ± 1.05 | |
F | — | 5.413 | 1.114 | 0.820 | 5.323 | |
p | — | 0.005 | 0.330 | 0.441 | 0.005 | |
CC | 273 | 4.96 ± 0.94 | 0.90 (0.52) | 1.76 ± 0.40 | 2.69 ± 0.88 | |
CT/TT | 78 | 5.05 ± 1.07 | 0.95 (0.40) | 1.68 ± 0.40 | 2.88 ± 0.90 | |
F | — | 0.287 | 0.063 | 1.727 | 1.594 | |
p | — | 0.592 | 0.803 | 0.190 | 0.208 |