Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation

Chen, Ning-Yuan; Liu, Cheng-Wu; Du, Li-Li; Xiao, Li-Ping; Ge, Lin; Wang, Yi-Yuan; Wei, Zhen; Wu, Hua-Yu; Luo, Chen-Yuan; Liang, Liang; Peng, Jun-Hua; Luo, Xiao-Qiu; Yin, Rui-Xing; Nguyen, Cuc Phuong; Pan, Shang-Ling

doi:10.1186/1476-511X-13-104

Lipids in Health and Disease

Table 5 Correlation between serum lipid parameters and the MTHFR C677T polymorphism

From: Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation

Group/Lipid	Relative factor	Unstandardized coefficients		Standardized coefficients	t	P
Group/Lipid	Relative factor	B	Std. error	Beta	t	P
All
TC	DBP	0.010	0.003	0.123	3.802	1.52E-4
	BMI	0.035	0.009	0.121	3.794	1.57E-4
	Sex	0.207	0.070	0.091	2.960	0.003
	Age	0.005	0.002	0.067	2.073	0.038
TG	BMI	0.016	0.002	0.265	8.754	8.59E-18
	SBP	0.001	0.000	0.094	3.099	0.002
HDL-C	Age	−0.005	0.001	−0.173	−5.532	4.04E-8
	BMI	−0.018	0.004	−0.156	−4.992	7.03E-7
	Sex	0.068	0.028	0.076	2.437	0.014
LDL-C	Age	0.011	0.002	0.169	5.247	1.88E-7
	DBP	0.008	0.002	0.115	3.599	3.35E-4
	BMI	0.027	0.008	0.102	3.228	0.001
	Sex	0.137	0.062	0.068	2.230	0.026
Male
TG	BMI	0.010	0.004	0.157	2.593	0.010
	Age	−0.002	0.001	−0.142	−2.343	0.020
	Genotype	−0.042	0.020	−0.127	−2.136	0.034
HDL-C	BMI	−0.029	0.008	−0.225	−3.700	2.62E-4
	Age	−0.005	0.002	−0.153	−2.522	0.012
Female
TC	DBP	0.009	0.003	0.117	3.052	0.002
	BMI	0.046	0.011	0.160	4.311	1.85E-5
	Age	0.009	0.003	0.118	3.078	0.002
TG	BMI	0.019	0.001	0.327	9.317	1.35E-19
	Age	0.002	0.001	0.169	4.822	1.73E-6
HDL-C	Age	−0.005	0.001	−0.183	−5.013	6.71E-7
	BMI	−0.015	0.004	−0.132	−3.601	3.38E-4
LDL-C	Age	0.013	0.002	0.199	5.176	2.94E-7
	BMI	0.030	0.009	0.117	3.184	0.002
	DBP	0.007	0.003	0.105	2.759	0.006
	Genotype	0.139	0.069	0.072	2.006	0.045
LG
TC	DBP	0.012	0.003	0.160	3.699	3.40E-4
	Sex	0.323	0.103	0.135	3.130	0.002
TG	BMI	0.007	0.002	0.160	3.708	2.32E-4
	Sex	0.046	0.016	0.120	2.779	0.006
HDL-C	BMI	−0.015	0.005	−0.145	−3.312	0.001
	DBP	0.001	0.001	0.103	2.359	0.019
LDL-C	DBP	0.008	0.003	0.124	2.857	0.004
	Sex	0.232	0.088	0.115	2.639	0.009
Male
TC	DBP	0.015	0.007	0.181	2.056	0.042
HDL-C	BMI	−0.026	0.011	−0.217	−2.480	0.014
LDL-C	DBP	0.014	0.006	0.200	2.277	0.024
Female
TC	DBP	0.011	0.004	0.154	3.072	0.002
	Genotype	0.215	0.103	0.104	2.087	0.038
TG	BMI	0.029	0.007	0.197	3.974	8.45E-5
	Genotype	0.117	0.047	0.124	2.511	0.012
HDL-C	Age	0.014	0.006	0.111	2.204	0.028
Non-LG
TC	BMI	0.081	0.013	0.263	6.047	2.92E-9
TG	BMI	0.097	0.013	0.324	7.598	1.54E-13
HDL-C	BMI	−0.019	0.006	−0.149	−3.314	0.001
	SBP	−0.002	0.001	−0.118	−2.636	0.009
	Sex	0.084	0.040	0.094	2.133	0.033
LDL-C	BMI	0.067	0.013	0.237	5.304	1.72E-7
	Age	0.022	0.008	0.120	2.691	0.007
Male
TC	BMI	0.061	0.027	0.189	2.307	0.023
	Age	−0.046	0.020	−0.186	−2.265	0.025
TG	Age	−0.064	0.021	−0.247	−3.066	0.003
	BMI	0.064	0.027	0.188	2.336	0.021
HDL-C	BMI	−0.033	0.012	−0.222	−2.698	0.008
LDL-C	BMI	0.064	0.025	0.212	2.569	0.011
Female
TC	BMI	0.087	0.016	0.285	5.553	5.57E-8
TG	BMI	0.103	0.014	0.364	7.294	2.03E-12
HDL-C	SBP	−0.003	0.001	−0.166	−3.126	0.002
	BMI	−0.015	0.007	−0.121	−2.281	0.023
LDL-C	BMI	0.060	0.015	0.216	3.983	8.28E-5
	Age	0.029	0.009	0.162	3.093	0.002
	DBP	0.012	0.004	0.139	2.632	0.009

Note: DBP, Diastolic blood pressure; SBP, Systolic blood pressure; BMI, Body mass index.

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ISSN: 1476-511X

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