Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations

Lin, Quan-Zhen; Yin, Rui-Xing; Guo, Tao; Wu, Jian; Sun, Jia-Qi; Shen, Shao-Wen; Shi, Guang-Yuan; Wu, Jin-Zhen; Liu, Cheng-Wu; Pan, Shang-Ling

doi:10.1186/1476-511X-13-123

Lipids in Health and Disease

Table 4 Relative risk factors for serum lipid parameters in the Mulao and Han populations

From: Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations

Lipid parameter	Risk factor	Unstandardized coefficient	Standard error	Standardized coefficient	t	P
Han/Mulao
TC	Age	0.010	0.002	0.168	5.242	0.000
TC	Genotype	−0.133	0.040	−0.087	−3.359	0.001
	Alcohol consumption	0.080	0.036	0.058	2.232	0.026
	Systolic blood pressure	0.004	0.001	0.083	2.867	0.004
	Body mass index	0.046	0.008	0.147	5.530	0.000
TG	Waist circumference	0.029	0.006	0.196	4.695	0.000
	Alcohol consumption	0.185	0.044	0.113	4.171	0.000
	Blood glucose	0.068	0.020	0.086	3.375	0.001
	Diastolic blood pressure	0.010	0.003	0.097	3.681	0.000
	Weight	0.095	0.025	0.723	3.796	0.000
	Height	−0.066	0.018	−0.442	−3.646	0.000
HDL-C	Waist circumference	−0.007	0.002	−0.109	−2.695	0.007
	Alcohol consumption	0.104	0.019	0.154	5.586	0.000
	Weight	−0.009	0.002	−0.175	−4.127	0.000
LDL-C	Body mass index	0.042	0.007	0.169	6.330	0.000
	Age	0.008	0.002	0.152	5.350	0.000
	Genotype	−0.083	0.032	−0.068	−2.611	0.009
	Alcohol consumption	−0.081	0.029	−0.074	−2.804	0.005
	Systolic blood pressure	0.002	0.001	0.059	2.044	0.041
ApoAI	Ethnic group	0.040	0.017	0.059	2.265	0.024
	Gender	0.059	0.021	0.087	2.774	0.006
	Age	0.001	0.001	0.052	2.007	0.045
	Alcohol consumption	0.130	0.014	0.284	9.210	0.000
	Waist circumference	−0.005	0.001	−0.125	−4.675	0.000
ApoB	Ethnic group	−0.122	0.021	−0.149	−5.772	0.000
	Body mass index	0.010	0.005	0.079	2.168	0.030
	Waist circumference	0.007	0.002	0.134	3.695	0.000
	Pulse pressure	0.003	0.001	0.117	4.464	0.000
	Blood glucose	0.019	0.007	0.07	2.657	0.008
ApoAI/ApoB	Ethnic group	0.103	0.032	0.083	3.256	0.001
	Gender	0.202	0.044	0.162	4.553	0.000
	Waist circumference	−0.013	0.003	−0.173	−4.086	0.000
	Blood glucose	−0.031	0.011	−0.077	−2.957	0.003
	Alcohol consumption	0.132	0.026	0.156	5.125	0.000
	Height	0.014	0.003	0.178	4.929	0.000
	Weight	−0.010	0.003	−0.145	−2.874	0.004
Han
TC	Age	0.009	0.003	0.150	3.613	0.000
	Waist circumference	0.022	0.005	0.182	4.702	0.000
	Systolic blood pressure	0.005	0.002	0.110	2.642	0.008
	Alcohol consumption	0.136	0.051	0.104	2.653	0.008
	Height	−0.011	0.005	−0.098	−2.401	0.017
TG	Waist circumference	0.056	0.006	0.329	9.030	0.000
	Blood glucose	0.121	0.030	0.141	4.076	0.000
	Alcohol consumption	0.240	0.065	0.129	3.697	0.001
	Diastolic blood pressure	0.010	0.004	0.086	2.422	0.016
HDL-C	Alcohol consumption	0.118	0.033	0.158	3.583	0.000
HDL-C	Waist circumference	−0.013	0.003	−0.195	−5.094	0.000
	Gender	0.222	0.055	0.206	4.067	0.000
	Cigarette smoking	0.142	0.047	0.141	3.022	0.003
	Age	0.003	0.001	0.080	2.178	0.030
LDL-C	Body mass index	0.044	0.009	0.185	5.085	0.000
LDL-C	Age	0.012	0.002	0.233	6.394	0.000
ApoAI	Gender	0.065	0.026	0.125	2.515	0.012
ApoAI	Alcohol consumption	0.142	0.015	0.394	9.480	0.000
	Weight	−0.007	0.001	−0.250	−6.288	0.000
	Cigarette smoking	0.092	0.021	0.189	4.308	0.000
ApoB	Waist circumference	0.006	0.001	0.254	4.621	0.000
	Systolic blood pressure	0.001	0.000	0.136	3.800	0.000
	Body mass index	0.007	0.003	0.120	2.207	0.028
	Blood glucose	0.014	0.004	0.118	3.411	0.001
	Gender	−0.060	0.016	−0.162	−3.712	0.000
	Height	−0.002	0.001	−0.105	−2.146	0.032
ApoAI/ApoB	Body mass index	−0.030	0.007	−0.214	−4.592	0.000
	Alcohol consumption	0.134	0.028	0.199	4.848	0.000
	Waist circumference	−0.011	0.003	−0.183	−3.850	0.000
	Gender	0.258	0.046	0.267	5.641	0.000
	Cigarette smoking	0.170	0.039	0.189	4.322	0.000
Mulao
TC	Age	0.010	0.003	0.142	3.874	0.000
	Body mass index	0.053	0.013	0.150	4.087	0.000
	Genotype	−0.207	0.060	−0.126	−3.432	0.001
TG	Waist circumference	0.021	0.006	0.171	3.296	0.001
	Alcohol consumption	0.136	0.051	0.095	2.669	0.008
	Body mass index	0.055	0.018	0.158	3.059	0.002
	Diastolic blood pressure	0.010	0.003	0.107	2.888	0.004
HDL-C	Body mass index	−0.041	0.005	−0.277	−7.641	0.000
HDL-C	Alcohol consumption	0.101	0.026	0.169	3.876	0.000
	Gender	0.084	0.039	0.093	2.126	0.034
LDL-C	Body mass index	0.046	0.010	0.170	4.610	0.000
	Age	0.007	0.002	0.127	3.467	0.001
	Genotype	−0.142	0.046	−0.113	−3.060	0.002
	Gender	0.149	0.061	0.090	2.440	0.015
ApoAI	Alcohol consumption	0.115	0.024	0.219	4.887	0.000
ApoAI	Waist circumference	−0.005	0.002	−0.100	−2.632	0.009
	Gender	0.073	0.036	0.091	1.995	0.046
ApoB	Waist circumference	0.010	0.002	0.162	4.367	0.000
ApoB	Pulse pressure	0.005	0.001	0.140	3.782	0.000
ApoAI/ApoB	Waist circumference	−0.018	0.003	−0.217	−5.846	0.000
	Blood glucose	−0.049	0.018	−0.102	−2.761	0.006
	Alcohol consumption	0.083	0.036	0.085	2.301	0.022

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, Apolipoprotein AI; ApoB, Apolipoprotein B. The correlative factors were determined by multivariable linear regression analysis with stepwise modeling.

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ISSN: 1476-511X

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