Efficacy of yogurt drink with added plant stanol esters (Benecol®, Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: a randomized placebo-controlled crossover trial NCT01461798

Table 4 Percentage changes in serum lipids from first-period baseline to the end of 4 weeks Benecol and to the end of placebo treatment and differences in responses between treatments

	Benecol		Placebo		Benecol^® vs. placebo		p¹
	Mean	(95% CI)	Mean	(95% CI)	Mean	(95% CI)	p¹
Total cholesterol	-7.7	(-10.5 to -4.9)	-0,5	(-4.0 to 3.1)	-7.2	(-11.1 to -3.3)	0.001
HDL cholesterol	-1,1	(-4.8 to 2.6)	-0,1	(-6.9 to 6.8)	-1.1	(-7.3 to 5.2)	0.735
LDL cholesterol measured	-10,4	(-14.0 to -6.9)	-0,1	(-5.1 to 4.9)	-10.3	(-14.3 to -6.4)	<0.001
LDL cholesterol calculated	-11,5	(-16.6 to -6.4)	0,7	(-5.6 to 7.0)	-12.2	(-17.3 to -7.2)	<0.001
Non-HDL cholesterol	-9,3	(-12.9 to -5.8)	0,2	(-4.5 to 5.0)	-9.6	(-14.1 to -5.0)	<0.001
TG³	18,2	(1.6 to 34.8)	18,2	(3.2 to 33.3)	0.0	(-18.9 to 18.9)	0.999

¹Test.
After logarithmic transformation the geometric means were 146.2 in Benecol^® and 149.4 in placebo (p = 0.76).

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