Cardiovascular and cancer events in hyper-high-density lipoprotein cholesterolemic patients: a post hoc analysis of the MEGA study

Table 2 Incidence of cardiovascular events according to high-density lipoprotein cholesterol level (5-year follow-up, all patients)

	Baseline high-density lipoprotein cholesterol (mg/dL)	No. of cardiovascular events (cardiovascular events/1000 person-years)	Hazard ratio	95% CI	p	p for trend
CHD	≤ 60	117/4896 (5.36)	1.0000		0.0066^a	0.4007
	> 60 to ≤ 90	23/2697 (1.88)	0.4784	0.3011–0.7600	0.0018
	> 90	2/239 (1.87)	0.5396	0.1280–2.2752	0.4007
Stroke	≤ 60	72/4896 (3.29)	1.0000		0.8803^a	0.9729
	> 60 to ≤ 90	27/2697 (2.21)	0.8870	0.5565–1.4140	0.6144
	> 90	0/239 (0.00)	0.0000	0.0000–0.0000	0.9729
Cerebral infarction	≤ 60	53/4896 (2.41)	1.0000		0.6707^a	0.9768
	> 60 to ≤ 90	17/2697 (1.39)	0.7696	0.4333–1.3670	0.3717
	> 90	0/239 (0.00)	0.0000	0.0000–0.0000	0.9768
CHD plus cerebral infarction	≤ 60	166/4896 (7.65)	1.0000		0.0048^a	0.1425
	> 60 to ≤ 90	40/2697 (3.28)	0.5733	0.4002–0.8212	0.0024
	> 90	2/239 (1.87)	0.3453	0.0834–1.4299	0.1425
Cardiovascular disease	≤ 60	199/4896 (9.21)	1.0000		0.0099^a	0.1043
	> 60 to ≤ 90	54/2697 (4.44)	0.6496	0.4746–0.8891	0.0071
	> 90	2/239 (1.87)	0.3094	0.0751–1.2742	0.1043
Total deaths	≤ 60	82/4896 (3.66)	1.0000		0.0927^a	0.2513
	> 60 to ≤ 90	26/2697 (2.09)	0.6335	0.4003–1.0023	0.0512
	> 90	1/239 (0.91)	0.3091	0.0416–2.2980	0.2513

CHD coronary heart disease, CI confidence interval.
^aP versus > 60 mg/dL group adjusted for age, sex, body mass index, hypertension, diabetes mellitus, low-density lipoprotein cholesterol, and smoking habit.