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Table 2 Incidence of cardiovascular events according to high-density lipoprotein cholesterol level (5-year follow-up, all patients)

From: Cardiovascular and cancer events in hyper-high-density lipoprotein cholesterolemic patients: a post hoc analysis of the MEGA study

  Baseline high-density lipoprotein cholesterol (mg/dL) No. of cardiovascular events (cardiovascular events/1000 person-years) Hazard ratio 95% CI p p for trend
CHD ≤ 60 117/4896 (5.36) 1.0000   0.0066a 0.4007
> 60 to ≤ 90 23/2697 (1.88) 0.4784 0.3011–0.7600 0.0018
> 90 2/239 (1.87) 0.5396 0.1280–2.2752 0.4007
Stroke ≤ 60 72/4896 (3.29) 1.0000   0.8803a 0.9729
> 60 to ≤ 90 27/2697 (2.21) 0.8870 0.5565–1.4140 0.6144
> 90 0/239 (0.00) 0.0000 0.0000–0.0000 0.9729
Cerebral infarction ≤ 60 53/4896 (2.41) 1.0000   0.6707a 0.9768
> 60 to ≤ 90 17/2697 (1.39) 0.7696 0.4333–1.3670 0.3717
> 90 0/239 (0.00) 0.0000 0.0000–0.0000 0.9768
CHD plus cerebral infarction ≤ 60 166/4896 (7.65) 1.0000   0.0048a 0.1425
> 60 to ≤ 90 40/2697 (3.28) 0.5733 0.4002–0.8212 0.0024
> 90 2/239 (1.87) 0.3453 0.0834–1.4299 0.1425
Cardiovascular disease ≤ 60 199/4896 (9.21) 1.0000   0.0099a 0.1043
> 60 to ≤ 90 54/2697 (4.44) 0.6496 0.4746–0.8891 0.0071
> 90 2/239 (1.87) 0.3094 0.0751–1.2742 0.1043
Total deaths ≤ 60 82/4896 (3.66) 1.0000   0.0927a 0.2513
> 60 to ≤ 90 26/2697 (2.09) 0.6335 0.4003–1.0023 0.0512
> 90 1/239 (0.91) 0.3091 0.0416–2.2980 0.2513
  1. CHD coronary heart disease, CI confidence interval.
  2. aP versus > 60 mg/dL group adjusted for age, sex, body mass index, hypertension, diabetes mellitus, low-density lipoprotein cholesterol, and smoking habit.