Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism

Table 2 Absolute (nmoles/gm brain tissue) and relative concentrations of PUFAs in the Control and PPA- intoxicated rats

Parameter	Group	N	Mean ± S.D.	Percent change	P value
α-Linolenic	Control	8	0.413 ± 0.070	100.00	0.004
α-Linolenic	Propionic acid	8	0.310 ± 0.019	74.98	0.004
Eicosapentaenoic	Control	8	0.428 ± 0.038	100.00	0.006
Eicosapentaenoic	Propionic acid	8	0.371 ± 0.033	86.70	0.006
Docosahexaenoic	Control	8	0.644 ± 0.066	100.00	0.001
Docosahexaenoic	Propionic acid	8	0.525 ± 0.047	81.60	0.001
Linoleic	Control	8	0.288 ± 0.045	100.00	0.001
Linoleic	Propionic acid	8	0.472 ± 0.042	163.78	0.001
γ-Linolenic	Control	8	0.434 ± 0.060	100.00	0.001
γ-Linolenic	Propionic acid	8	0.144 ± 0.012	33.22	0.001
Arachidonic	Control	8	0.385 ± 0.040	100.00	0.001
Arachidonic	Propionic acid	8	0.306 ± 0.030	79.44	0.001
Total omega 3	Control	8	1.072 ± 0.228	100.00	0.001
Total omega 3	Propionic acid	8	0.819 ± 0.077	72.20	0.001
Total omega 6	Control	8	0.896 ± 0.097	100.00	0.001
Total omega 6	Propionic acid	8	0.45 ± 0.033	83.3	0.001
omega 6/Omega3	Control	8	0.836 ± 0.056	100.00	0.001
omega 6/Omega3	Propionic acid	8	0.502 ± 0.026	100.27	0.001
α-Linolenic/Linoleic	Control	8	1.466 ± 0.314	100.00	0.001
α-Linolenic/Linoleic	Propionic acid	8	0.671 ± 0.066	45.78	0.001
α-Linolenic/EPA	Control	8	0.978 ± 0.194	100.00	NS
α-Linolenic/EPA	Propionic acid	8	0.831 ± 0.080	85.00	NS
α-Linolenic/DHA	Control	8	0.648 ± 0.138	100.00	NS
α-Linolenic/DHA	Propionic acid	8	0.625 ± 0.079	96.49	NS
EPA/DHA	Control	8	0.665 ± 0.041	100.00	NS
EPA/DHA	Propionic acid	8	0.712 ± 0.106	107.15	NS
ARA/Linoleic	Control	8	1.133 ± 0.081	100.00	0.001
ARA/Linoleic	Propionic acid	8	0.644 ± 0.065	43.15	0.001
ARA/EPA	Control	8	0.901 ± 0.123	100.00	NS
ARA/EPA	Propionic acid	8	0.829 ± 0.124	91.98	NS

ISSN: 1476-511X