Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?

Table 3 Fatty acid profiles of S _f 60 − 400 fractions in response to acute docosahexaenoic acid intake in carriers ( E4 +) and non-carriers ( E4 −) of an APOE4 allele

		Fasting	Postprandial	Change	P values
		(relative%)	(relative%)	(Δ)	*Interaction*	*Genotype*	*Time*
16:0	E4+	29.01 ± 1.35	30.21 ± 0.74	+ 1.20	0.981	0.688	0.063^†
16:0	E4−	28.54 ± 0.73	29.77 ± 0.73	+ 1.23	0.981	0.688	0.063^†
18:0	E4+	9.15 ± 1.27	5.96 ± 0.65	− 3.19	0.452	0.534	<0.001
18:0	E4−	8.07 ± 0.71	5.80 ± 0.47	− 2.27	0.452	0.534	<0.001
16:1 n − 7	E4+	3.12 ± 0.39	2.34 ± 0.36	− 0.78	0.676	0.823	<0.001
16:1 n − 7	E4−	3.27 ± 0.27	2.38 ± 0.24	− 0.89	0.676	0.823	<0.001
18:1 n − 9	E4+	28.93 ± 0.12	30.29 ± 0.81	+ 1.36	0.307	0.326	0.415
18:1 n − 9	E4−	30.52 ± 0.52	30.36 ± 0.42	− 0.16	0.307	0.326	0.415
18:2 n − 6	E4+	15.84 ± 0.66	17.41 ± 0.48	+ 1.57	0.883	0.912	0.001
18:2 n − 6	E4−	15.97 ± 0.55	17.42 ± 0.55	+ 1.45	0.883	0.912	0.001
20:4 n − 6	E4+	1.91 ± 0.17	2.05 ± 0.14	+ 0.14	0.648	0.449	0.047
20:4 n − 6	E4−	2.03 ± 0.16	2.25 ± 0.16	+ 0.22	0.648	0.449	0.047
18:3 n − 3	E4+	1.64 ± 0.19	1.35 ± 0.12	− 0.29	0.791	0.409	0.018
18:3 n − 3	E4−	1.49 ± 0.09	1.25 ± 0.10	− 0.24	0.791	0.409	0.018
20:5 n − 3	E4+	1.19 ± 0.13	1.25 ± 0.04	− 0.06	0.526	0.948	0.154
20:5 n − 3	E4−	1.32 ± 0.30	1.15 ± 0.11	− 0.17	0.526	0.948	0.154
22:6 n − 3	E4+	3.74 ± 0.43	4.33 ± 0.33	+ 0.59	0.878	0.497	0.099
22:6 n − 3	E4−	3.44 ± 0.45	3.91 ± 0.47	+ 0.47	0.878	0.497	0.099

Values are presented as mean relative percentages ± SEM or as change (Δ) compared to fasted state (i.e.% at postprandial value –% at fasting value). P values were obtained using a Factorial Repeated Measures (Split-Plot) ANOVA in SPSS version 22.0 (IBM Corp., Armonk, NY). Bold characters are used to indicate significant effects (P < 0.05). ^†Trend effect was set at P < 0.09.

ISSN: 1476-511X