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Table 5 Distribution of genotype and allele frequencies of the APOB polymorphisms with the major variables analyzed among the Kuwaiti population (n = 795)

From: Genetic association of APOB polymorphisms with variation in serum lipid profile among the Kuwait population

 

TC

TG

HDL-C

LDL-C

FH-HC

FH-HTG

 

Normal (≤5.17)

High (>5.17)

Normal (≤1.70)

High (>1.70)

Normal (>1.1 men & >1.29 women)

Abnormal (≤1.1 men & ≤1.29 women)

Normal (≤3.2)

High (>3.2)

Absent

Present

Absent

Present

n

475

191

571

95

211

418

389

238

409

197

594

12

APOB signal peptide (rs11279109)

            

II n (%)

277 (58.3)

118 (61.8)

338 (57.4)

67 (70.5)

118 (55.9)

258 (61.7)

233 (59.9)

141 (59.2)

248 (60.64)

121 (61.42)

364 (61.28)

5 (41.67)

ID n (%)

172 (36.2)

59 (30.9)

210 (36.8)

21 (22.1)

81 (38.4)

135 (32.3)

134 (34.5)

82 (34.5)

138 (33.7)

63 (32.0)

198 (33.3)

3 (25.0)

DD n (%)

26 (5.5)

14 (7.3)

33 (5.8)

7 (7.4)

12 (5.7)

25 (6.0)

22 (5.7)

15 (6.3)

23 (5.6)

13 (6.6)

32 (5.4)

4 (33.3)

p

0.338

 

0.021

 

0.313

 

0.944

 

0.839

 

0.004

 

D (f)

0.236

0.228

0.242

0.184

0.249

0.221

0.229

0.235

0.225

0.226

0.221

0.458

I (f)

0.764

0.772

0.758

0.816

0.751

0.779

0.771

0.765

0.775

0.774

0.779

0.542

p

0.754

 

0.083

 

0.274

 

0.791

 

0.970

 

0.006

 

APOB Codon 2488C (rs693)

            

X X n (%)

239 (50.3)

104 (54.5)

292 (51.1)

51 (53.7)

111 (52.6)

217 (52.6)

206 (53.0)

122 (51.3)

226 (55.3)

106 (53.8)

326 (54.9)

6 (50.0)

X + X- n (%)

199 (41.9)

73 (38.2)

234 (41.0)

38 (40.0)

84 (39.8)

168 (40.2)

152 (39.1)

98 (41.2)

153 (37.4)

79 (40.1)

229 (38.6)

3 (25.0)

X + X + n (%)

37 (7.8)

14 (7.3)

45 (7.9)

6 (6.3)

16 (7.6)

33 (7.9)

31 (8.0)

18 (7.6)

30 (7.3)

12 (6.1)

39 (6.6)

3 (25.0)

p

0.625

 

0.826

 

0.982

 

0.871

 

0.741

 

0.041

 

X (f)

0.713

0.736

0.716

0.737

0.725

0.720

0.725

0.718

0.740

0.739

0.742

0.625

X + (f)

0.287

0.264

0.284

0.263

0.275

0.280

0.275

0.282

0.260

0.261

0.258

0.375

p

0.399

 

0.559

 

0.851

 

0.805

 

0.969

 

0.198

 

APOB Codon 3611–MspI G (rs1801701)

            

M + M + n (%)

407(85.7)

172(90.1)

494(86.5)

85(89.5)

180(85.3)

368(88.0)

337(86.6)

209(87.8)

362(88.5)

162(82.2)

516(86.9)

8(66.7)

M + M n (%)

65(13.7)

18(9.4)

75(13.1)

8(8.4)

30(14.2)

47(11.2)

49(12.6)

28(11.8)

45(11.0)

35(17.8)

76(12.8)

4(33.3)

M M n (%)

3(0.6)

1(0.5)

2(0.4)

2(2.1)

1(0.5)

3(0.7)

3(0.8)

1(0.4)

2(0.5)

0(0.0)

2(0.3)

0(0.0)

p

0.315

 

0.058

 

0.532

 

0.822

 

0.046

 

0.113

 

M (f)

0.075

0.052

0.069

0.063

0.076

0.063

0.071

0.063

0.060

0.089

0.067

0.167

M + (f)

0.925

0.948

0.931

0.937

0.924

0.937

0.929

0.937

0.940

0.911

0.933

0.833

p

0.143

 

0.761

 

0.407

 

0.600

 

0.063

 

0.079

 

APOB Codon 4154G (rs1042031)

            

E + E + n (%)

383(80.6)

154(80.6)

461(80.7)

76(80.0)

174(82.5)

334(79.9)

319(82.0)

187(78.6)

321(78.5)

158(80.2)

468(78.8)

11(91.7)

E + E n (%)

83(17.5)

35(18.3)

102(17.9)

16(16.8)

34(16.1)

77(18.4)

63(16.2)

48(20.2)

82(20.0)

33(16.8)

114(19.2)

1(8.3)

E E n (%)

8(1.9)

2(1.1)

8(1.4)

3(3.2)

3(1.4)

7(1.7)

7(1.8)

3(1.3)

6(1.5)

6(3.0)

12(2.0)

0(0.0)

p

0.723

 

0.455

 

0.743

 

0.406

 

0.289

 

0.543

 

E (f)

0.106

0.102

0.103

0.116

0.095

0.109

0.099

0.113

0.115

0.114

0.116

0.042

E + (f)

0.894

0.898

0.897

0.884

0.905

0.891

0.901

0.887

0.885

0.886

0.884

0.958

p

0.820

 

0.604

 

0.441

 

0.416

 

0.971

 

0.257

 

APOB 3 VNTR

            

MM n (%)

391(82.3)

157(82.2)

466(81.6)

82(86.3)

174(82.5)

345(82.5)

321(82.5)

197(82.8)

339(82.9)

168(85.3)

496(83.5)

11(91.7)

ML n (%)

68(14.3)

30(15.7)

88(15.4)

10(10.5)

30(14.2)

62(14.8)

56(14.4)

35(14.7)

56(13.7)

22(11.2)

77(13.0)

1(8.3)

LL n (%)

16(3.4)

4(2.1)

17(3.0)

3(3.2)

7(3.3)

11(2.6)

12(3.1)

6(2.5)

14(3.4)

7(3.6

21(3.5)

0(0.0)

p

0.633

 

0.461

 

0.875

 

0.916

 

0.685

 

0.700

 

L (f)

0.105

0.099

0.107

0.084

0.104

0.100

0.103

0.099

0.103

0.091

0.100

0.042

M (f)

0.895

0.901

0.893

0.916

0.896

0.900

0.897

0.901

0.897

0.909

0.900

0.958

p

0.754

 

0.343

 

0.834

 

0.816

 

0.537

 

0.503

 
  1. TC total cholesterol (expressed in mmol/L); TG triglycerides (expressed in mmol/L); LDL-C low density lipoprotein-cholesterol; HDL-C high density lipoprotein-cholesterol; FH-HTG positive family history of hypertriglyceridemia, FH-HC positive family history of hypercholesterolemia.
  2. n = number of samples,% = frequency for each genotype in percent and ratio (f) for the allele.
  3. The p-values were determined by chi-square test at a significance level of p = 0.05.