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Table 7 Association of the major haplotypes analyzed at the APOB gene locus and their association with variation in mean serum lipid levels (expressed in mmol/L) among the Kuwaiti samples analyzed

From: Genetic association of APOB polymorphisms with variation in serum lipid profile among the Kuwait population

Lipid

Haplotype

A

B

C

D

E

F

G

O

N

Non-carrier

1675

2032

2094

2165

2219

2236

2283

1788

 

Carrier

681

324

262

191

137

120

73

568

TC

Non-carrier

4.67 ± 0.02

4.69 ± 0.02

4.69 ± 0.02

4.69 ± 0.02

4.69 ± 0.02

4.69 ± 0.02

4.69 ± 0.02

4.70 ± 0.02

 

Carrier

4.72 ± 0.04

4.71 ± 0.05

4.70 ± 0.06

4.69 ± 0.07

4.73 ± 0.09

4.61 ± 0.10

4.68 ± 0.11

4.65 ± 0.04

 

p value*

0.356

0.767

0.879

0.937

0.667

0.417

0.935

0.298

TG

Non-carrier

1.00 ± 0.02

1.07 ± 0.03

1.01 ± 0.02

1.01 ± 0.02

1.01 ± 0.02

1.01 ± 0.02

1.01 ± 0.02

1.03 ± 0.02

 

Carrier

1.05 ± 0.05

1.05 ± 0.03

1.00 ± 0.05

0.97 ± 0.05

1.05 ± 0.08

1.02 ± 0.09

0.86 ± 0.07

0.95 ± 0.03

 

p value*

0.334

0.728

0.914

0.998

0.440

0.707

0.048

0.089

HDL-C

Non-carrier

1.14 ± 0.01

1.12 ± 0.01

1.13 ± 0.01

1.13 ± 0.01

1.14 ± 0.01

1.14 ± 0.01

1.13 ± 0.01

1.14 ± 0.01

 

Carrier

1.14 ± 0.02

1.14 ± 0.01

1.16 ± 0.02

1.16 ± 0.03

1.11 ± 0.03

1.10 ± 0.03

1.20 ± 0.04

1.13 ± 0.01

 

p value*

0.800

0.180

0.238

0.334

0.324

0.204

0.147

0.577

LDL-C

Non-carrier

3.12 ± 0.02

3.13 ± 0.03

3.12 ± 0.02

3.12 ± 0.02

3.11 ± 0.02

3.11 ± 0.02

3.12 ± 0.02

3.12 ± 0.02

 

Carrier

3.11 ± 0.05

3.11 ± 0.03

3.11 ± 0.05

3.10 ± 0.06

3.17 ± 0.07

3.12 ± 0.09

3.10 ± 0.11

3.10 ± 0.04

 

p value*

0.935

0.688

0.954

0.816

0.476

0.923

0.866

0.568

  1. The table shows the mean and standard deviation (SD) of serum lipid levels using univariate Anova (UNIANOVA). A two-tailed (t-test) p-value of 0.05 was considered as statistical significance. The carrier status is defined as a sample which has all five alleles associated with the given haplotype and their count (N) is given. A sample may have more than one haplotype since the gametic phase is unknown.
  2. N count number; TC total cholesterol; TG triglycerides; LDL-C low density lipoprotein-cholesterol; HDL-C high density lipoprotein-cholesterol.
  3. *t-test p-value of 0.05 was considered as statistical significance.